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Anti-Dimethyl (Lys9), Phospho (Ser10) Histone H3 [6HH3-2C5]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets Histone H3 Dimethyl (Lys9)-Phospho (Ser10)
Reactivity Human and Mouse
Relevance Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Host Mouse
Immunogen Ovalbumin conjugated synthetic peptide: AR[dimethyl-K][phospho- S]TGGKAPRKQL-(C) corresponding to aa 7-20 of Histone H3 (17 kDa). This sequence is conserved in a wide range of species.
Subclass IgG1 kappa
Notes Available in 100ul unit as ascites.
Research Area Cancer, Cell Signaling & Signal Transduction, DNA Damage and Repair, Epigenetics & Nuclear Signalling, Metabolism

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