Anti-ESR1 [ER-F3]
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| Applications | ELISA IF IP WB ChIP-seq |
| Antigen/Gene or Protein Targets | Estrogen receptor a (F region) |
| Reactivity | Human |
| Relevance | The Monoclonal anti‐Human Estrogen Receptor a does not cross react with chicken.. Other reactivities have not been evaluated. Estrogen receptors are activated by the hormone estrogen (17β-estradiol). Once activated by estrogen, the ER is able to translocate into the nucleus and acts as a a DNA-binding transcription factor. ERa and ERb regulate gene transcription by direct binding to estrogen-regulated elements (ERE) or indirectly by protein-protein interaction with transcription factor activator protein-1 (AP-1) and Sp1. Estrogens are important for mammary gland morphogenesis and differentiation. |
| Host | Mouse |
| Immunogen | SLQKYYITG-EAEGFPAVT (synthetic peptide corresponding to amino acids 578‐595 of human ER alpha) |
| Subclass | IgG1 kappa |
| Notes |
Available in 100ul unit as ascites. Recommended dilutions: 1/500‐1/5000 For IP and Gel Shift: 1/10‐1/20 |
| Research Area | Cancer, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Neurobiology |
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