Anti-CSB [1CSB-1A11]
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Info
| Applications | ELISA IF WB |
| Antigen/Gene or Protein Targets | CSB (Cockayne syndrome B protein) |
| Reactivity | Human |
| Relevance | Monoclonal anti-CSB, clone 1CSB-1A11, has been validated for ELISA, Western Blot and Immunocytochemistry. Cockayne syndrome (CS), also called Neill-Dingwall syndrome, is a rare autosomal recessive neurodegenerative disorder characterized by growth failure, impaired development of the nervous system, abnormal sensitivity to sunlight (photosensitivity), eye disorders and premature aging. Mutations in the ERCC8 (also known as CSA) gene or the ERCC6 (also known as CSB) gene are the cause of Cockayne syndrome. Mutations in the ERCC6 gene mutation makes up ~70% of cases. The proteins made by these genes are involved in repairing damaged DNA via the transcription-coupled repair mechanism, particularly the DNA in active genes. |
| Host | Mouse |
| Immunogen | RYRDDGDEDYYKQRLRRWNK (Synthetic peptide corresponding to aa 451-470 of human CSB) |
| Subclass | IgG1 kappa |
| Notes |
Available in 100ul unit as ascites. Recommended dilutions: 1/500-1/5000 |
| Research Area | DNA Damage and Repair, Epigenetics & Nuclear Signalling, Neurobiology |
References: 2 entries
Bradsher et al. 2002. Mol Cell. 10(4):819-29. PMID: 12419226.
CSB is a component of RNA pol I transcription.
Europe PMC ID: 12419226
Add a reference
References: 2 entries
Bradsher et al. 2002. Mol Cell. 10(4):819-29. PMID: 12419226.
CSB is a component of RNA pol I transcription.
Europe PMC ID: 12419226
Add a reference
References: 2 entries
Bradsher et al. 2002. Mol Cell. 10(4):819-29. PMID: 12419226.
CSB is a component of RNA pol I transcription.
Add a reference
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