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|Applications||IHC IF WB|
|Antigen/Gene or Protein Targets||Ataxin3|
|Reactivity||Human, Mouse and Rat|
|Relevance||The Anti-Ataxin3 antibody, clone 2SCA-1H9 can be used to study wild type ataxin-3 and the mutant form with polyglutamine expansion found in patients affected with spinocerebellar ataxin type 3/Machado-Joseph disease (SCA3/MJD). In analysis of human tissues by western blot, 1H9 antibody revealed several isoforms of ataxin-3 (presumably generated by alternative splicing, Trottier et al. 1998). 1H9 antibody detected polyglutamine aggregate (or nuclear inclusions) by IHC on SCA-3/MJD brain sections (Paulson et al.1997).|
|Immunogen||Recombinant protein (112-249)|
Available in 100ul unit as ascites.
Specificity for human, monkey, rat and mouse ataxin-3 isoforms. The epitope was mapped precisely at E214-L233.
|Research Area||Epigenetics & Nuclear Signalling, Neurobiology|
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