Anti-ATXN3 [2SCA-1H9]
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| Applications | IHC IF WB |
| Antigen/Gene or Protein Targets | Ataxin3 |
| Reactivity | Human, Mouse and Rat |
| Relevance | The Anti-Ataxin3 antibody, clone 2SCA-1H9 can be used to study wild type ataxin-3 and the mutant form with polyglutamine expansion found in patients affected with spinocerebellar ataxin type 3/Machado-Joseph disease (SCA3/MJD). In analysis of human tissues by western blot, 1H9 antibody revealed several isoforms of ataxin-3 (presumably generated by alternative splicing, Trottier et al. 1998). 1H9 antibody detected polyglutamine aggregate (or nuclear inclusions) by IHC on SCA-3/MJD brain sections (Paulson et al.1997). |
| Host | Mouse |
| Immunogen | Recombinant protein (112-249) |
| Subclass | IgG1 kappa |
| Notes |
Available in 100ul unit as ascites. Specificity for human, monkey, rat and mouse ataxin-3 isoforms. The epitope was mapped precisely at E214-L233. |
| Research Area | Epigenetics & Nuclear Signalling, Neurobiology |
References: 2 entries
Trottier et al. 1998. Neurobiol Dis. 5(5):335-47. PMID: 10069576.
Paulson et al. 1997. Neuron. 19(2):333-44. PMID: 9292723.
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References: 2 entries
Trottier et al. 1998. Neurobiol Dis. 5(5):335-47. PMID: 10069576.
Paulson et al. 1997. Neuron. 19(2):333-44. PMID: 9292723.
Add a reference
References: 2 entries
Trottier et al. 1998. Neurobiol Dis. 5(5):335-47. PMID: 10069576.
Paulson et al. 1997. Neuron. 19(2):333-44. PMID: 9292723.
Add a reference
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