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Anti-Nesprin-2 [K20-478]

Info

Applications EM ELISA FACS IHC IP WB
Antigen/Gene or Protein Targets Nesprin-2 (NUANCE: NUcleus ans ActiN Connecting Element)
Reactivity Human
Relevance Giant isoforms, encoded by Nesprin-1 (Syne1) and Nesprin-2 (Syne2), are multifunctional actin-binding and nuclear-envelope-associated proteins belonging to the spectrin superfamily. Nesprins play pivotal roles in maintenance of nuclear envelope integrity, nuclear positioning, and anchorage to the cytoskeleton and the centrosome. Although compelling evidence underlines nesprin's roles in several human diseases that range from cerebellar ataxia to dystrophy-like phenotypes; the underlying molecular mechanisms remain elusive.
Host Mouse
Immunogen Residues 1-459 of Nesprin-2
Notes Disease associations: Laminopathies, nucleoenvelopathies and nuclear biology
Research Area Cell Type or Organelle Marker, Cell Signaling & Signal Transduction

References: 6 entries

Neumann et al. 2010. J Biol Chem. 285(45):34932-8. PMID: 20801886.

Nesprin-2 interacts with {alpha}-catenin and regulates Wnt signaling at the nuclear envelope.

Europe PMC ID: 20801886

Libotte et al. 2005. Mol Biol Cell. 16(7):3411-24. PMID: 15843432.

Lamin A/C-dependent localization of Nesprin-2, a giant scaffolder at the nuclear envelope.

Europe PMC ID: 15843432

Zhen et al. 2002. J Cell Sci. 115(Pt 15):3207-22. PMID: 12118075.

NUANCE, a giant protein connecting the nucleus and actin cytoskeleton.

Europe PMC ID: 12118075


Add a reference

References: 6 entries

Neumann et al. 2010. J Biol Chem. 285(45):34932-8. PMID: 20801886.

Nesprin-2 interacts with {alpha}-catenin and regulates Wnt signaling at the nuclear envelope.

Europe PMC ID: 20801886

Libotte et al. 2005. Mol Biol Cell. 16(7):3411-24. PMID: 15843432.

Lamin A/C-dependent localization of Nesprin-2, a giant scaffolder at the nuclear envelope.

Europe PMC ID: 15843432

Zhen et al. 2002. J Cell Sci. 115(Pt 15):3207-22. PMID: 12118075.

NUANCE, a giant protein connecting the nucleus and actin cytoskeleton.

Europe PMC ID: 12118075


Add a reference

References: 6 entries

Neumann et al. 2010. J Biol Chem. 285(45):34932-8. PMID: 20801886.

Nesprin-2 interacts with {alpha}-catenin and regulates Wnt signaling at the nuclear envelope.

Libotte et al. 2005. Mol Biol Cell. 16(7):3411-24. PMID: 15843432.

Lamin A/C-dependent localization of Nesprin-2, a giant scaffolder at the nuclear envelope.

Zhen et al. 2002. J Cell Sci. 115(Pt 15):3207-22. PMID: 12118075.

NUANCE, a giant protein connecting the nucleus and actin cytoskeleton.


Add a reference


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