Anti-phospho Pax3 [Ser209] monoclonal antibody
Invented by Dr. Andrew Hollenbach
Invented at LSU Health Sciences Center New Orleans
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- References (2)
- Inventor Info
Info
| Catalogue Number | 156473 |
| Applications | WB |
| Antigen/Gene or Protein Targets | Phosphorylated Ser209 of Pax3 |
| Reactivity | Human and Mouse |
| Relevance | Pax3 is a transcription factor important for myogenesis and when dysregulated can cause pediatric solid muscle tumor alveolar rhabdomyosarcoma (ARMS). ARMS is primarily characterized by the t(2;13)(p35;p14) chromosomal translocation, which results in the oncogenic fusion protein Pax3-FOXO1. Using these phospho-specific antibodies it was demonstrated that the pattern of Pax3 phosphorylation at serines 201, 205, and 209 changes throughout early myogenic differentiation and that this pattern is different for Pax3-FOXO1 in primary myoblasts and in several ARMS cell lines. |
| Host | Rat |
| Immunogen | synthetic peptide: NH2-DID(pS)EPDLPLKRC-CO2 |
| Positive Control | IgG |
| Research Area | Cancer |
References: 2 entries
Loupe et al. 2015. Oncogenesis. 4:e145. PMID: 25821947.
Dietz et al. 2011. Int J Biochem Cell Biol. 43(6):936-45. PMID: 21440083.
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References: 2 entries
Loupe et al. 2015. Oncogenesis. 4:e145. PMID: 25821947.
Dietz et al. 2011. Int J Biochem Cell Biol. 43(6):936-45. PMID: 21440083.
Add a reference
Inventor Information
Inventors
|
Dr. Andrew Hollenbach |
