Cytotoxic Monoclonal Antibody A1 against human pluripotent stem cells
Invented by Andre Choo
Invented at A*STAR Accelerate Technologies Pte Ltd
- References (2)
- Inventor Info
|Antigen/Gene or Protein Targets
|hPSCs (Human Pluripotent Stem Cells)
Monoclonal antibody (mAb), TAG-A1 (A1), was generated to selectively kill residual undifferentiated human embryonic stem cells (hESC) so as to prevent teratoma formation upon transplantation of hESC-derived products.
A1 induces hESC oncosis via binding-initiated signaling cascade, most likely by ligating receptors on surface microvilli. The ability to evoke excess reactive oxygen species (ROS) production via the Nox2 isoform of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is critical in the cell death pathway.
|Stem Cell Biology, Apoptosis and Programmed Cell Death
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