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Cytotoxic Monoclonal Antibody A1 against human pluripotent stem cells
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Invented by Andre Choo
Invented at A*STAR Accelerate Technologies Pte Ltd

Info

Catalogue Number 154125
Antigen/Gene or Protein Targets hPSCs (Human Pluripotent Stem Cells)
Reactivity Human
Notes Monoclonal antibody (mAb), TAG-A1 (A1), was generated to selectively kill residual undifferentiated human embryonic stem cells (hESC) so as to prevent teratoma formation upon transplantation of hESC-derived products.
A1 induces hESC oncosis via binding-initiated signaling cascade, most likely by ligating receptors on surface microvilli. The ability to evoke excess reactive oxygen species (ROS) production via the Nox2 isoform of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is critical in the cell death pathway.
Research Area Stem Cell Biology, Apoptosis and Programmed Cell Death

References

There are 2 reference entries for this reagent.

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References: 2 entries

Zheng et al. 2017. Cell Death Differ. 24(3):546-558. PMID: 28106884.

Excess reactive oxygen species production mediates monoclonal antibody-induced human embryonic stem cell death via oncosis.

Europe PMC ID: 28106884


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References: 2 entries

Zheng et al. 2017. Cell Death Differ. 24(3):546-558. PMID: 28106884.

Excess reactive oxygen species production mediates monoclonal antibody-induced human embryonic stem cell death via oncosis.


Add a reference