Trex1 T303P Mouse
Invented at Wake Forest University
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 154029 |
| Antigen/Gene or Protein Targets | TREX1 |
| Disease Keywords | Lupus |
| Model | Mutant |
| Relevance | TREX1 encodes a DNA exonuclease and mutations in this gene result in multiple autoimmune disorders, including lupus. This particular mouse model mimics Aicardi-Goutières Syndrome, a form of Lupus. |
| Conditional | No |
| Mouse Genetic Background/Cross History | Mutant mice were generated on a 129S6/SvEvTac background using an allelic replacement strategy. |
| Research Area | Immunology, Neurobiology, Cell Signaling & Signal Transduction, Drug Discovery & Development |
References: 2 entries
Grieves et al. 2015. Proc Natl Acad Sci U S A. 112(16):5117-22. PMID: 25848017.
Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease.
Europe PMC ID: 25848017
Add a reference
References: 2 entries
Grieves et al. 2015. Proc Natl Acad Sci U S A. 112(16):5117-22. PMID: 25848017.
Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease.
Add a reference
