peQE30-HisNter-TDP1-102 L27A-L28A Vector
Invented by Prof Emanuele Buratti from International Centre For Genetic Engineering And Biotechnology (ICGEB)
Invented at International Centre For Genetic Engineering And Biotechnology (ICGEB)
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 153790 |
| Backbone Size (bp) | 3461 |
| Bacterial Resistance | Ampicillin |
| Vector Type | pQE30 |
| Synonyms | TARDBP, TAR DNA Binding Protein, TDP-43, TAR DNA-Binding Protein 43, ALS10 |
| Antigen/Gene or Protein Targets | Mutant TDP43 N-terminal domain 1-102 |
| Relevance | The TAR DNA-binding protein (TDP-43) is a highly conserved heterogeneous nuclear ribonucleoprotein (hnRNP) that controls the transcription, splicing and RNA stability of specific genes. The protein associates with single-stranded RNA and DNA sequences, and exhibits remarkable specificity for UG/TG dinucleotide repeats. Regulation of the human low-molecular-weight neurofilament (hNFL) by TDP-43 has also been reported to occur through 3′ UTR recruitment. TDP-43 is the major protein in inclusions from patients suffering from frontotemporal lobar degeneration (FTLD) with ubiquitin-positive inclusions and amyotrophic lateral sclerosis (ALS). This is a mutant N-terminal domain of TDP-43 that cannot fold properly |
| Research Area | Gene Expression, Neurobiology, Virology |
| Notes | Concentration 1.8mg/ml |
References: 2 entries
Mompeán et al. 2017. J Biol Chem. 292(28):11992-12006. PMID: 28566288.
Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions.
Europe PMC ID: 28566288
Add a reference
References: 2 entries
Mompeán et al. 2017. J Biol Chem. 292(28):11992-12006. PMID: 28566288.
Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions.
Add a reference
