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peQE30-HisNter-TDP1-102 L27A-L28A Vector

Invented by Prof Emanuele Buratti at International Centre For Genetic Engineering And Biotechnology

Info

Catalogue Number 153790
Backbone Size (bp) 3461
Bacterial Resistance Ampicillin
Vector Type pQE30
Synonyms TARDBP, TAR DNA Binding Protein, TDP-43, TAR DNA-Binding Protein 43, ALS10
Antigen/Gene or Protein Targets Mutant TDP43 N-terminal domain 1-102
Relevance The TAR DNA-binding protein (TDP-43) is a highly conserved heterogeneous nuclear ribonucleoprotein (hnRNP) that controls the transcription, splicing and RNA stability of specific genes. The protein associates with single-stranded RNA and DNA sequences, and exhibits remarkable specificity for UG/TG dinucleotide repeats. Regulation of the human low-molecular-weight neurofilament (hNFL) by TDP-43 has also been reported to occur through 3′ UTR recruitment. TDP-43 is the major protein in inclusions from patients suffering from frontotemporal lobar degeneration (FTLD) with ubiquitin-positive inclusions and amyotrophic lateral sclerosis (ALS). This is a mutant N-terminal domain of TDP-43 that cannot fold properly
Research Area Gene Expression, Neurobiology, Virology
Notes Concentration 1.8mg/ml

References

There are 2 reference entries for this reagent.

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References: 2 entries

Mompeán et al. 2017. J Biol Chem. 292(28):11992-12006. PMID: 28566288.

Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions.

Europe PMC ID: 28566288


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References: 2 entries

Mompeán et al. 2017. J Biol Chem. 292(28):11992-12006. PMID: 28566288.

Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions.


Add a reference