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Anti-TP73, Polyclonal [TP73]

Info

Applications ELISA WB
Antigen/Gene or Protein Targets TP73
Reactivity Human and Mouse
Relevance Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro­apoptotic, isoforms lacking the domain are anti­apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. This gene encodes a member of the p53 family of transcription factors involved
in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain
multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, however, the biological validity and the full­length nature of most variants have not been determined [provided by RefSeq].
Host Rabbit
Immunogen 3 synthetic peptides (human) conjugated to KLH
Formulation 0.5 X PBS, containing a final concentration of 50% Glycerol, 0.1% BSA and 0.01% Thimerosal.
Method of Purification Immunogen affinity purification
Molecular Weight (kDa) 69.6 [Isoform Alpha]
54.3 [Isoform Beta]
53 [Isoform Gamma]
44.5 [Isoform Delta]
61.7 [Isoform Epsilon]
59.9 [Isoform Zeta]
64.4 [Isoform dN­Alpha]
49.1 [Isoform dN­Beta]
47.8 [Isoform dN­Gamma]
Research Area Cancer, Cell Cycle, DNA Damage and Repair, Epigenetics & Nuclear Signalling

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