Anti-TP73, Polyclonal [TP73]
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Info
| Applications | ELISA WB |
| Antigen/Gene or Protein Targets | TP73 |
| Reactivity | Human and Mouse |
| Relevance |
Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are proapoptotic, isoforms lacking the domain are antiapoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, however, the biological validity and the fulllength nature of most variants have not been determined [provided by RefSeq]. |
| Host | Rabbit |
| Immunogen | 3 synthetic peptides (human) conjugated to KLH |
| Formulation | 0.5 X PBS, containing a final concentration of 50% Glycerol, 0.1% BSA and 0.01% Thimerosal. |
| Method of Purification | Immunogen affinity purification |
| Molecular Weight (kDa) |
69.6 [Isoform Alpha] 54.3 [Isoform Beta] 53 [Isoform Gamma] 44.5 [Isoform Delta] 61.7 [Isoform Epsilon] 59.9 [Isoform Zeta] 64.4 [Isoform dNAlpha] 49.1 [Isoform dNBeta] 47.8 [Isoform dNGamma] |
| Research Area | Cancer, Cell Cycle, DNA Damage and Repair, Epigenetics & Nuclear Signalling |
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