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Anti-PDGFR [PDGFR-B2]

Info

Applications IF IP
Antigen/Gene or Protein Targets PDGFR
Reactivity Human and Pig
Relevance This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.
Host Mouse
Subclass IgG2b
Myeloma Used P3X63Ag8.653
Research Area Cancer

References: 1 entry

Rönnstrand et al. 1988. J Biol Chem. 263(21):10429-35. PMID: 2455716.


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References: 1 entry

Rönnstrand et al. 1988. J Biol Chem. 263(21):10429-35. PMID: 2455716.


Add a reference

References: 1 entry

Rönnstrand et al. 1988. J Biol Chem. 263(21):10429-35. PMID: 2455716.


Add a reference


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