Anti-PDGFR [PDGFR-B2]
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Info
| Applications | IF IP |
| Antigen/Gene or Protein Targets | PDGFR |
| Reactivity | Human and Pig |
| Relevance | This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. |
| Host | Mouse |
| Subclass | IgG2b |
| Myeloma Used | P3X63Ag8.653 |
| Research Area | Cancer |
References: 1 entry
References: 1 entry
References: 1 entry
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