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Info
Applications | IF IP |
Antigen/Gene or Protein Targets | PDGFR |
Reactivity | Human and Pig |
Relevance | This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. |
Host | Mouse |
Subclass | IgG2b |
Myeloma Used | P3X63Ag8.653 |
Research Area | Cancer |