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Anti-Dimethyl Histone H3 (Lys9) [4HH3-2A12]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets Histone H3 (Dimethyl-Lys9) (17 kDa).
Reactivity N/A
Relevance The Monoclonal anti‐dimethyl‐Histone H3 (Lys9) antibody, clone 4HH3‐2A12, has been validated for ELISA, Western Blot, immunofluorescence and immunoprecipitation. Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure. Histone H3 is the most extensively modified of the five histones and is an important protein in the emerging field of epigenetics, where its sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes. Di- and Tri-methylation of Lysine 9 are associated with repression and heterochromatin, while mono-methylation of K4 is associated with active genes.
Host Mouse
Immunogen Ovalbumin conjugated synthetic peptide (TAR[dimethyl‐K]STGGKAPRC) corresponding to aa 6‐17 of Histone H3. This sequence is conserved in a wide range of species.
Subclass IgG2a kappa
Notes Available in 100ul unit as ascites.

Recommended dilutions: 1/500‐1/5000
Research Area Cancer, Cell Signaling & Signal Transduction, DNA Damage and Repair, Epigenetics & Nuclear Signalling, Metabolism

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