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Anti-Frataxin [2FRA-1G2]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets  Frataxin 
Reactivity Human
Relevance The monoclonal anti-FRATAXIN antibody, clone 2FRA‐1G2 recognises human Frataxin. Frataxin is localized to the mitochondrion. The function of frataxin is not entirely clear, but it seems to be involved in assembly of iron-sulfur clusters. It has been proposed to act as either an iron chaperone or an iron storage protein. Its mRNA is predominantly expressed in tissues with a high metabolic rate (including liver, kidney, brown fat and heart). Reduced expression of frataxin is the cause of Friedreich's ataxia (FRDA), a lethal neurodegenerative disease. An overexpression of frataxin in Drosophila has shown an increase in antioxidant capability, resistance to oxidative stress insults and longevity.
Host Mouse
Immunogen TrpE‐Frataxin full length
Subclass IgG1 kappa
Notes Available in 100ul unit as ascites.

Recommended dilutions : 1/5000 for western blot 1/100‐1/1000 for immunofluorescence
Research Area Cancer, Cell Type or Organelle Marker, Epigenetics & Nuclear Signalling, Metabolism, Neurobiology

References: 8 entries

Koutnikova et al. 1998. Hum Mol Genet. 7(9):1485-9. PMID: 9700204.

Bidichandani et al. 1998. Am J Hum Genet. 62(1):111-21. PMID: 9443873.

Rötig et al. 1997. Nat Genet. 17(2):215-7. PMID: 9326946.

Campuzano et al. 1997. Hum Mol Genet. 6(11):1771-80. PMID: 9302253.

Rötig et al. 1997. Nat Genet. 17(2):215-7. PMID: 9326946.

Foury et al. 1997. FEBS Lett. 411(2-3):373-7. PMID: 9271239.

Babcock et al. 1997. Science. 276(5319):1709-12. PMID: 9180083.

Campuzano et al. 1996. Science. 271(5254):1423-7. PMID: 8596916.


Add a reference

References: 8 entries

Koutnikova et al. 1998. Hum Mol Genet. 7(9):1485-9. PMID: 9700204.

Bidichandani et al. 1998. Am J Hum Genet. 62(1):111-21. PMID: 9443873.

Rötig et al. 1997. Nat Genet. 17(2):215-7. PMID: 9326946.

Campuzano et al. 1997. Hum Mol Genet. 6(11):1771-80. PMID: 9302253.

Rötig et al. 1997. Nat Genet. 17(2):215-7. PMID: 9326946.

Foury et al. 1997. FEBS Lett. 411(2-3):373-7. PMID: 9271239.

Babcock et al. 1997. Science. 276(5319):1709-12. PMID: 9180083.

Campuzano et al. 1996. Science. 271(5254):1423-7. PMID: 8596916.


Add a reference

References: 8 entries

Koutnikova et al. 1998. Hum Mol Genet. 7(9):1485-9. PMID: 9700204.

Bidichandani et al. 1998. Am J Hum Genet. 62(1):111-21. PMID: 9443873.

Rötig et al. 1997. Nat Genet. 17(2):215-7. PMID: 9326946.

Campuzano et al. 1997. Hum Mol Genet. 6(11):1771-80. PMID: 9302253.

Rötig et al. 1997. Nat Genet. 17(2):215-7. PMID: 9326946.

Foury et al. 1997. FEBS Lett. 411(2-3):373-7. PMID: 9271239.

Babcock et al. 1997. Science. 276(5319):1709-12. PMID: 9180083.

Campuzano et al. 1996. Science. 271(5254):1423-7. PMID: 8596916.


Add a reference


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