Anti-E6 [1E-6F4]
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| Applications | ELISA IF WB |
| Antigen/Gene or Protein Targets | E6 Papillomavirus Type16 |
| Reactivity | Virus |
| Relevance | The E6 of human papillomavirus type 16 (HPV16) is a 158 aa protein expressed in transformed human cells after infection. E6 protein mediates the degradation of the cellular p53 tumour suppressor protein. It activates transcription of the telomerase gene and acts as a DNA binding protein with high affinity for four‐way DNA junctions. In addition to p53, E6 interacts with a variety of cellular proteins, of which a significant number act at the transcriptional level. E6 is present in a large number of cervical carcinomas. |
| Host | Mouse |
| Immunogen | Recomb prot |
| Subclass | IgG1 kappa |
| Notes | Available in 100ul unit as ascites. |
| Research Area | Cancer, Virology |
References: 3 entries
Masson et al. 2003. J Gen Virol. 84(Pt 8):2099-104. PMID: 12867640.
Choulier et al. 2001. J Immunol Methods. 249(1-2):253-64. PMID: 11226482.
Giovane et al. 1999. J Mol Recognit. 12(2):141-52. PMID: 10398405.
Add a reference
References: 3 entries
Masson et al. 2003. J Gen Virol. 84(Pt 8):2099-104. PMID: 12867640.
Choulier et al. 2001. J Immunol Methods. 249(1-2):253-64. PMID: 11226482.
Giovane et al. 1999. J Mol Recognit. 12(2):141-52. PMID: 10398405.
Add a reference
References: 3 entries
Masson et al. 2003. J Gen Virol. 84(Pt 8):2099-104. PMID: 12867640.
Choulier et al. 2001. J Immunol Methods. 249(1-2):253-64. PMID: 11226482.
Giovane et al. 1999. J Mol Recognit. 12(2):141-52. PMID: 10398405.
Add a reference
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