Anti-E6 [1E-6F4]
- Datasheet
- References (6)
- Inventor Info
Info
| Applications | ELISA IF WB |
| Antigen/Gene or Protein Targets | E6 Papillomavirus Type16 |
| Reactivity | Virus |
| Relevance | The E6 of human papillomavirus type 16 (HPV16) is a 158 aa protein expressed in transformed human cells after infection. E6 protein mediates the degradation of the cellular p53 tumour suppressor protein. It activates transcription of the telomerase gene and acts as a DNA binding protein with high affinity for four‐way DNA junctions. In addition to p53, E6 interacts with a variety of cellular proteins, of which a significant number act at the transcriptional level. E6 is present in a large number of cervical carcinomas. |
| Host | Mouse |
| Immunogen | Recomb prot |
| Subclass | IgG1 kappa |
| Notes | Available in 100ul unit as ascites. |
| Research Area | Cancer, Virology |
References: 6 entries
Masson et al. 2003. J Gen Virol. 84(Pt 8):2099-104. PMID: 12867640.
Preferential nuclear localization of the human papillomavirus type 16 E6 oncoprotein in cervical carcinoma cells.
Europe PMC ID: 12867640
Choulier et al. 2001. J Immunol Methods. 249(1-2):253-64. PMID: 11226482.
Delineation of a linear epitope by multiple peptide synthesis and phage display.
Europe PMC ID: 11226482
Giovane et al. 1999. J Mol Recognit. 12(2):141-52. PMID: 10398405.
Targetting of the N-terminal domain of the human papillomavirus type 16 E6 oncoprotein with monomeric ScFvs blocks the E6-mediated degradation of cellular p53.
Europe PMC ID: 10398405
Add a reference
References: 6 entries
Masson et al. 2003. J Gen Virol. 84(Pt 8):2099-104. PMID: 12867640.
Preferential nuclear localization of the human papillomavirus type 16 E6 oncoprotein in cervical carcinoma cells.
Choulier et al. 2001. J Immunol Methods. 249(1-2):253-64. PMID: 11226482.
Delineation of a linear epitope by multiple peptide synthesis and phage display.
Giovane et al. 1999. J Mol Recognit. 12(2):141-52. PMID: 10398405.
Targetting of the N-terminal domain of the human papillomavirus type 16 E6 oncoprotein with monomeric ScFvs blocks the E6-mediated degradation of cellular p53.
Add a reference
