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Gfi1 1b/1b Mouse

Info

Antigen/Gene or Protein Targets Growth factor independence 1 (Gfi1)
Relevance A knock-in mouse model was created in which the Gfi1 coding region was replaced by Gfi1b.

The Gfi1 (1b/1b)-mice did not exhibit significant defects in the hematopoietic system as previously described for Gfi1 (-/-)-mice, suggesting that Gfi1b is able to rescue the loss of Gfi1-function.

However, the Gfi1 (1b/1b)-mice showed significant defects in inner ear development i.e. hair cell formation leading to hearing loss.

These results point to some interesting mechanisms on the molecular level to the differentiation and maintenance of hearing. This makes the Gfi1 (1b/1b)-model a valuable tool for the development of novel approaches for treating hearing loss.
Production Details Gfi1:Gfi1b knock-in mice were generated by modifying the previously described Gfi1:GFP knock-in construct. The constructs were transfected in R1 ES cells and selection with G418 and ganciclovir was carried out.
Conditional No
Growth/Phenotype Keywords Defects in inner ear development e.g hair cell formation leading to hearing loss
Research Area Cancer, Epigenetics & Nuclear Signalling, Genetic Studies Tools

References: 8 entries

Fiolka et al. 2006. EMBO Rep. 7(3):326-33. PMID: 16397623.

Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development.

Europe PMC ID: 16397623

Möröy et al. 2005. Int J Biochem Cell Biol. 37(3):541-6. PMID: 15618011.

The zinc finger transcription factor Growth factor independence 1 (Gfi1).

Europe PMC ID: 15618011

Wallis et al. 2003. Development. 130(1):221-32. PMID: 12441305.

The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival.

Europe PMC ID: 12441305

Saleque et al. 2002. Genes Dev. 16(3):301-6. PMID: 11825872.

The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages.

Europe PMC ID: 11825872


Add a reference

References: 8 entries

Fiolka et al. 2006. EMBO Rep. 7(3):326-33. PMID: 16397623.

Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development.

Europe PMC ID: 16397623

Möröy et al. 2005. Int J Biochem Cell Biol. 37(3):541-6. PMID: 15618011.

The zinc finger transcription factor Growth factor independence 1 (Gfi1).

Europe PMC ID: 15618011

Wallis et al. 2003. Development. 130(1):221-32. PMID: 12441305.

The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival.

Europe PMC ID: 12441305

Saleque et al. 2002. Genes Dev. 16(3):301-6. PMID: 11825872.

The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages.

Europe PMC ID: 11825872


Add a reference

References: 8 entries

Fiolka et al. 2006. EMBO Rep. 7(3):326-33. PMID: 16397623.

Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development.

Möröy et al. 2005. Int J Biochem Cell Biol. 37(3):541-6. PMID: 15618011.

The zinc finger transcription factor Growth factor independence 1 (Gfi1).

Wallis et al. 2003. Development. 130(1):221-32. PMID: 12441305.

The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival.

Saleque et al. 2002. Genes Dev. 16(3):301-6. PMID: 11825872.

The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages.


Add a reference


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