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Gfi1 1b/1b Mouse

Info

Antigen/Gene or Protein Targets Growth factor independence 1 (Gfi1)
Relevance A knock-in mouse model was created in which the Gfi1 coding region was replaced by Gfi1b.

The Gfi1 (1b/1b)-mice did not exhibit significant defects in the hematopoietic system as previously described for Gfi1 (-/-)-mice, suggesting that Gfi1b is able to rescue the loss of Gfi1-function.

However, the Gfi1 (1b/1b)-mice showed significant defects in inner ear development i.e. hair cell formation leading to hearing loss.

These results point to some interesting mechanisms on the molecular level to the differentiation and maintenance of hearing. This makes the Gfi1 (1b/1b)-model a valuable tool for the development of novel approaches for treating hearing loss.
Production Details Gfi1:Gfi1b knock-in mice were generated by modifying the previously described Gfi1:GFP knock-in construct. The constructs were transfected in R1 ES cells and selection with G418 and ganciclovir was carried out.
Conditional No
Growth/Phenotype Keywords Defects in inner ear development e.g hair cell formation leading to hearing loss
Research Area Cancer, Epigenetics & Nuclear Signalling, Genetic Studies Tools

References: 4 entries

Fiolka et al. 2006. EMBO Rep. 7(3):326-33. PMID: 16397623.

Möröy et al. 2005. Int J Biochem Cell Biol. 37(3):541-6. PMID: 15618011.

Wallis et al. 2003. Development. 130(1):221-32. PMID: 12441305.

Saleque et al. 2002. Genes Dev. 16(3):301-6. PMID: 11825872.


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References: 4 entries

Fiolka et al. 2006. EMBO Rep. 7(3):326-33. PMID: 16397623.

Möröy et al. 2005. Int J Biochem Cell Biol. 37(3):541-6. PMID: 15618011.

Wallis et al. 2003. Development. 130(1):221-32. PMID: 12441305.

Saleque et al. 2002. Genes Dev. 16(3):301-6. PMID: 11825872.


Add a reference

References: 4 entries

Fiolka et al. 2006. EMBO Rep. 7(3):326-33. PMID: 16397623.

Möröy et al. 2005. Int J Biochem Cell Biol. 37(3):541-6. PMID: 15618011.

Wallis et al. 2003. Development. 130(1):221-32. PMID: 12441305.

Saleque et al. 2002. Genes Dev. 16(3):301-6. PMID: 11825872.


Add a reference


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