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Anti-Integrin aVβ6 [Avβ6 62ow.17]


Catalogue Number 151623
Applications IHC WB
Antigen/Gene or Protein Targets Integrin avß6
Reactivity Human
Relevance Alpha-v beta-6 is upregulated on cancers and during tissue remodelling but is weak absent on resting adult tissues. It promotes invasion and correlates with poor survival. It is likely to be good therapeutic target.
Host Rat
Immunogen Mouse fibroblasts retrovirally infected with cDNA to human beta6 (3T3β6.19). Cells expressed a mouse/human avβ6 chimera.
Subclass IgG1
Positive Control BT20 breast carcinoma, original immunogen.
Recommended Growing Conditions DMEM containing glucose(4.5g/litre), bicarbonate(3.7g/litre), glutamine (4 x 10-3 M), penicillin(50U/ml), streptomycin(50ug/ml)and neomycin(100ug/ml). Also straight DMEM or RPMI 1640 with 3% FCS.
Notes Does not recognise mouse avβ6
Research Area Cell Structure and Motility

References: 1 entry

Marsh et al. 2008. Cancer Res. 68(9):3295-303. PMID: 18451156.

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