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Anti-BZLF1 [BZ.1]

Info

Catalogue Number 151473
Applications ELISA FACS IF IP WB
Antigen/Gene or Protein Targets BZLF1
Reactivity Virus
Relevance The Epstein-Barr Virus (EBV), also called Human herpesvirus 4 (HHV-4), is a virus of the herpes family and is one of the most common viruses in humans. BZLF1 functions as a transcriptional activator of EBV early gene expression and is essential for the viral transition between latent and lytic replication. In addition to its role in the EBV life cycle, BZLF1 also has profound effects upon the host cellular environment, including disruption of cell cycle regulation, signal transduction pathways, and transcription.
Host Mouse
Immunogen Full length recombinant EBV antigen ZEBRA (BZLF1)
Subclass IgG1
Positive Control B95.8 & P3HR-1 cell lines (induced with phorbol ester to give greater percentage positive) or Akata-BL induced with anti-IgG.
Myeloma Used P3X63Ag8.653
Recommended Growing Conditions RPMI 1640/10% FCS/1mM pyruvate/Pen&Strep (supplement with 10% BM Condimed HI (Roche Diagnostics) if the cells are poor or slwo to grow.)
Strain Balb/c
Notes Reactivity: Epstein-Barr Virus (EBV)
Research Area Cell Cycle, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Virology

References: 5 entries

Robinson et al. 2011. J Virol. 85(17):8940-53. PMID: 21697476.

Bristol et al. 2010. J Virol. 84(23):12362-74. PMID: 20861254.

Inman et al. 2001. J Virol. 75(5):2400-10. PMID: 11160743.

FACS IF

Young et al. 1991. J Virol. 65(6):2868-74. PMID: 1851858.

Rowe et al. 1991. J Exp Med. 173(1):147-58. PMID: 1845872.

IF


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