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Anti-BZLF1 [BZ.1]

Invented by Prof Martin Rowe at University Of Birmingham

Info

Catalogue Number 151473
Applications ELISA FACS IF IP WB
Antigen/Gene or Protein Targets BZLF1
Reactivity Virus
Relevance The Epstein-Barr Virus (EBV), also called Human herpesvirus 4 (HHV-4), is a virus of the herpes family and is one of the most common viruses in humans. BZLF1 functions as a transcriptional activator of EBV early gene expression and is essential for the viral transition between latent and lytic replication. In addition to its role in the EBV life cycle, BZLF1 also has profound effects upon the host cellular environment, including disruption of cell cycle regulation, signal transduction pathways, and transcription.
Host Mouse
Immunogen Full length recombinant EBV antigen ZEBRA (BZLF1)
Subclass IgG1
Positive Control B95.8 & P3HR-1 cell lines (induced with phorbol ester to give greater percentage positive) or Akata-BL induced with anti-IgG.
Myeloma Used P3X63Ag8.653
Recommended Growing Conditions RPMI 1640/10% FCS/1mM pyruvate/Pen&Strep (supplement with 10% BM Condimed HI (Roche Diagnostics) if the cells are poor or slwo to grow.)
Strain Balb/c
Notes Reactivity: Epstein-Barr Virus (EBV)
Research Area Cell Cycle, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Virology

References: 10 entries

Robinson et al. 2011. J Virol. 85(17):8940-53. PMID: 21697476.

Cellular transcription factor Oct-1 interacts with the Epstein-Barr virus BRLF1 protein to promote disruption of viral latency.

Europe PMC ID: 21697476

Bristol et al. 2010. J Virol. 84(23):12362-74. PMID: 20861254.

The Epstein-Barr virus BZLF1 protein inhibits tumor necrosis factor receptor 1 expression through effects on cellular C/EBP proteins.

Europe PMC ID: 20861254

Inman et al. 2001. J Virol. 75(5):2400-10. PMID: 11160743.

FACS IF

Activators of the Epstein-Barr virus lytic program concomitantly induce apoptosis, but lytic gene expression protects from cell death.

Europe PMC ID: 11160743

Young et al. 1991. J Virol. 65(6):2868-74. PMID: 1851858.

Differentiation-associated expression of the Epstein-Barr virus BZLF1 transactivator protein in oral hairy leukoplakia.

Europe PMC ID: 1851858

Epstein-Barr virus (EBV)-associated lymphoproliferative disease in the SCID mouse model: implications for the pathogenesis of EBV-positive lymphomas in man.

Europe PMC ID: 1845872

Rowe et al. 1991. J Exp Med. 173(1):147-58. PMID: 1845872.

IF


Add a reference

References: 10 entries

Robinson et al. 2011. J Virol. 85(17):8940-53. PMID: 21697476.

Cellular transcription factor Oct-1 interacts with the Epstein-Barr virus BRLF1 protein to promote disruption of viral latency.

Europe PMC ID: 21697476

Bristol et al. 2010. J Virol. 84(23):12362-74. PMID: 20861254.

The Epstein-Barr virus BZLF1 protein inhibits tumor necrosis factor receptor 1 expression through effects on cellular C/EBP proteins.

Europe PMC ID: 20861254

Inman et al. 2001. J Virol. 75(5):2400-10. PMID: 11160743.

FACS IF

Activators of the Epstein-Barr virus lytic program concomitantly induce apoptosis, but lytic gene expression protects from cell death.

Europe PMC ID: 11160743

Young et al. 1991. J Virol. 65(6):2868-74. PMID: 1851858.

Differentiation-associated expression of the Epstein-Barr virus BZLF1 transactivator protein in oral hairy leukoplakia.

Europe PMC ID: 1851858

Epstein-Barr virus (EBV)-associated lymphoproliferative disease in the SCID mouse model: implications for the pathogenesis of EBV-positive lymphomas in man.

Europe PMC ID: 1845872

Rowe et al. 1991. J Exp Med. 173(1):147-58. PMID: 1845872.

IF


Add a reference

References: 10 entries

Robinson et al. 2011. J Virol. 85(17):8940-53. PMID: 21697476.

Cellular transcription factor Oct-1 interacts with the Epstein-Barr virus BRLF1 protein to promote disruption of viral latency.

Bristol et al. 2010. J Virol. 84(23):12362-74. PMID: 20861254.

The Epstein-Barr virus BZLF1 protein inhibits tumor necrosis factor receptor 1 expression through effects on cellular C/EBP proteins.

Inman et al. 2001. J Virol. 75(5):2400-10. PMID: 11160743.

FACS IF

Activators of the Epstein-Barr virus lytic program concomitantly induce apoptosis, but lytic gene expression protects from cell death.

Young et al. 1991. J Virol. 65(6):2868-74. PMID: 1851858.

Differentiation-associated expression of the Epstein-Barr virus BZLF1 transactivator protein in oral hairy leukoplakia.

Epstein-Barr virus (EBV)-associated lymphoproliferative disease in the SCID mouse model: implications for the pathogenesis of EBV-positive lymphomas in man.

Rowe et al. 1991. J Exp Med. 173(1):147-58. PMID: 1845872.

IF


Add a reference


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