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Catalogue Number
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160702 |
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Synonyms
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L-cis hydroxyproline biphenyl ester (Lc-BPE)
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Type
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Inhibitor
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Relevance
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Lc-BPE is the highest affinity novel chemical tool for characterizing the role of Alanine-Serine-Cysteine Transporter 2 (ASCT2), a sodium-dependent transporter in a variety of tissues, in cancer and other diseases from this study. This ASCT2 inhibitor additionally provides insights into design for future clinically relevant compounds. Lc-BPW is the first inhibitor of ASCTs with sub-µM affinity (Garibsingh et al., 2020).
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On Target IC50
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10µM
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Selectivity
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Stereoselective
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In vivo applications
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molecular docking, electrophysiology, transport assays in proteoliposomes and cryo-EM structure determination of ASCT2
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Research Area
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Cancer, Cardiovascular, Drug Discovery & Development, Other
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