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ASCT2 Inhibitor

Invented at Binghamton University

Info

Catalogue Number 160702
Synonyms L-cis hydroxyproline biphenyl ester (Lc-BPE)
Type Inhibitor
Relevance Lc-BPE is the highest affinity novel chemical tool for characterizing the role of Alanine-Serine-Cysteine Transporter 2 (ASCT2), a sodium-dependent transporter in a variety of tissues, in cancer and other diseases from this study. This ASCT2 inhibitor additionally provides insights into design for future clinically relevant compounds. Lc-BPW is the first inhibitor of ASCTs with sub-µM affinity (Garibsingh et al., 2020).
On Target IC50 10µM
Selectivity Stereoselective
In vivo applications molecular docking, electrophysiology, transport assays in proteoliposomes and cryo-EM structure determination of ASCT2
Research Area Cancer, Cardiovascular, Drug Discovery & Development, Other

References

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References: 1 entry

doi: https://doi.org/10.1101/2020.05.29.124305


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References: 1 entry

doi: https://doi.org/10.1101/2020.05.29.124305


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