Anti-HLADR [BU43]
Invented at University Of Birmingham
- Datasheet
- References (14)
- Inventor Info
Info
| Catalogue Number | 151438 |
| Applications | FACS IHC IP RIA |
| Antigen/Gene or Protein Targets | Human Leukocyte Antigen-DR locus (HLA-DR) associated invariant chain (CD74) |
| Synonyms | CD74 Molecule; HLA-DR Antigens-Associated Invariant Chain; Gamma Chain Of Class II Antigens; Ia-Associated Invariant Chain; MHC HLA-DR Gamma Chain; DHLAG; P33; CD74 Antigen; Ia-GAMMA; HLADG |
| Reactivity | Human |
| Relevance | HLA-DR-associated invariant chain (CD74) plays a role in antigen presentation. In addition to its expression on antigen-presenting cells, CD74 is expressed by carcinomas of renal, lung, gastric, and thymic origin and by certain sarcomas. The restricted expression of CD74 by normal tissues and its very rapid internalization make CD74 an attractive therapeutic target for both cancer and immunologic diseases. It has also been shown to have value as a gastric carcinoma marker. |
| Host | Mouse |
| Immunogen | HFB1 plasmacytoid cell line |
| Subclass | IgM |
| Myeloma Used | NS0 |
| Recommended Growing Conditions | RPMI 1640 + 10% FCS |
| Strain | Balb/c |
| Research Area | Immunology |
References: 14 entries
Gregers et al. 2003. Int Immunol. 15(11):1291-9. PMID: 14565927.
MHC class II loading of high or low affinity peptides directed by Ii/peptide fusion constructs: implications for T cell activation.
Europe PMC ID: 14565927
Nordeng et al. 2002. Mol Biol Cell. 13(6):1846-56. PMID: 12058053.
The cytoplasmic tail of invariant chain regulates endosome fusion and morphology.
Europe PMC ID: 12058053
Nordeng et al. 1999. J Biol Chem. 274(30):21139-48. PMID: 10409667.
Overexpression of proteins containing tyrosine- or leucine-based sorting signals affects transferrin receptor trafficking.
Europe PMC ID: 10409667
Moldenhauer et al. 1999. Immunology. 96(3):473-84. PMID: 10233730.
Surface-expressed invariant chain (CD74) is required for internalization of human leucocyte antigen-DR molecules to early endosomal compartments.
Europe PMC ID: 10233730
Rudy et al. 1997. J Immunol. 158(5):2116-25. PMID: 9036956.
The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of B lymphoblastoid cells.
Europe PMC ID: 9036956
Koch et al. 1991. J Immunol. 147(8):2643-51. PMID: 1918985.
Rapid intracellular pathway gives rise to cell surface expression of the MHC class II-associated invariant chain (CD74).
Europe PMC ID: 1918985
Wraight et al. 1990. J Biol Chem. 265(10):5787-92. PMID: 1690714.
Human major histocompatibility complex class II invariant chain is expressed on the cell surface.
Europe PMC ID: 1690714
Add a reference
References: 14 entries
Gregers et al. 2003. Int Immunol. 15(11):1291-9. PMID: 14565927.
MHC class II loading of high or low affinity peptides directed by Ii/peptide fusion constructs: implications for T cell activation.
Nordeng et al. 2002. Mol Biol Cell. 13(6):1846-56. PMID: 12058053.
The cytoplasmic tail of invariant chain regulates endosome fusion and morphology.
Nordeng et al. 1999. J Biol Chem. 274(30):21139-48. PMID: 10409667.
Overexpression of proteins containing tyrosine- or leucine-based sorting signals affects transferrin receptor trafficking.
Moldenhauer et al. 1999. Immunology. 96(3):473-84. PMID: 10233730.
Surface-expressed invariant chain (CD74) is required for internalization of human leucocyte antigen-DR molecules to early endosomal compartments.
Rudy et al. 1997. J Immunol. 158(5):2116-25. PMID: 9036956.
The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of B lymphoblastoid cells.
Koch et al. 1991. J Immunol. 147(8):2643-51. PMID: 1918985.
Rapid intracellular pathway gives rise to cell surface expression of the MHC class II-associated invariant chain (CD74).
Wraight et al. 1990. J Biol Chem. 265(10):5787-92. PMID: 1690714.
Human major histocompatibility complex class II invariant chain is expressed on the cell surface.
Add a reference
