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Anti-HLADR [BU43]


Catalogue Number 151438
Applications FACS IHC IP RIA
Antigen/Gene or Protein Targets Human Leukocyte Antigen-DR locus (HLA-DR) associated invariant chain (CD74)
Synonyms CD74 Molecule; HLA-DR Antigens-Associated Invariant Chain; Gamma Chain Of Class II Antigens; Ia-Associated Invariant Chain; MHC HLA-DR Gamma Chain; DHLAG; P33; CD74 Antigen; Ia-GAMMA; HLADG
Reactivity Human
Relevance HLA-DR-associated invariant chain (CD74) plays a role in antigen presentation. In addition to its expression on antigen-presenting cells, CD74 is expressed by carcinomas of renal, lung, gastric, and thymic origin and by certain sarcomas. The restricted expression of CD74 by normal tissues and its very rapid internalization make CD74 an attractive therapeutic target for both cancer and immunologic diseases. It has also been shown to have value as a gastric carcinoma marker.
Host Mouse
Immunogen HFB1 plasmacytoid cell line
Subclass IgM
Myeloma Used NS0
Recommended Growing Conditions RPMI 1640 + 10% FCS
Strain Balb/c
Research Area Immunology

References: 7 entries

Gregers et al. 2003. Int Immunol. 15(11):1291-9. PMID: 14565927.

Nordeng et al. 2002. Mol Biol Cell. 13(6):1846-56. PMID: 12058053.

Nordeng et al. 1999. J Biol Chem. 274(30):21139-48. PMID: 10409667.

Moldenhauer et al. 1999. Immunology. 96(3):473-84. PMID: 10233730.

Rudy et al. 1997. J Immunol. 158(5):2116-25. PMID: 9036956.

Koch et al. 1991. J Immunol. 147(8):2643-51. PMID: 1918985.

Wraight et al. 1990. J Biol Chem. 265(10):5787-92. PMID: 1690714.

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