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Anti-HLADR [BU43]

Info

Catalogue Number 151438
Applications FACS IHC IP RIA
Antigen/Gene or Protein Targets Human Leukocyte Antigen-DR locus (HLA-DR) associated invariant chain (CD74)
Synonyms CD74 Molecule; HLA-DR Antigens-Associated Invariant Chain; Gamma Chain Of Class II Antigens; Ia-Associated Invariant Chain; MHC HLA-DR Gamma Chain; DHLAG; P33; CD74 Antigen; Ia-GAMMA; HLADG
Reactivity Human
Relevance HLA-DR-associated invariant chain (CD74) plays a role in antigen presentation. In addition to its expression on antigen-presenting cells, CD74 is expressed by carcinomas of renal, lung, gastric, and thymic origin and by certain sarcomas. The restricted expression of CD74 by normal tissues and its very rapid internalization make CD74 an attractive therapeutic target for both cancer and immunologic diseases. It has also been shown to have value as a gastric carcinoma marker.
Host Mouse
Immunogen HFB1 plasmacytoid cell line
Subclass IgM
Myeloma Used NS0
Recommended Growing Conditions RPMI 1640 + 10% FCS
Strain Balb/c
Research Area Immunology

References: 14 entries

Gregers et al. 2003. Int Immunol. 15(11):1291-9. PMID: 14565927.

MHC class II loading of high or low affinity peptides directed by Ii/peptide fusion constructs: implications for T cell activation.

Europe PMC ID: 14565927

Nordeng et al. 2002. Mol Biol Cell. 13(6):1846-56. PMID: 12058053.

The cytoplasmic tail of invariant chain regulates endosome fusion and morphology.

Europe PMC ID: 12058053

Nordeng et al. 1999. J Biol Chem. 274(30):21139-48. PMID: 10409667.

Overexpression of proteins containing tyrosine- or leucine-based sorting signals affects transferrin receptor trafficking.

Europe PMC ID: 10409667

Moldenhauer et al. 1999. Immunology. 96(3):473-84. PMID: 10233730.

Surface-expressed invariant chain (CD74) is required for internalization of human leucocyte antigen-DR molecules to early endosomal compartments.

Europe PMC ID: 10233730

Rudy et al. 1997. J Immunol. 158(5):2116-25. PMID: 9036956.

The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of B lymphoblastoid cells.

Europe PMC ID: 9036956

Koch et al. 1991. J Immunol. 147(8):2643-51. PMID: 1918985.

Rapid intracellular pathway gives rise to cell surface expression of the MHC class II-associated invariant chain (CD74).

Europe PMC ID: 1918985

Wraight et al. 1990. J Biol Chem. 265(10):5787-92. PMID: 1690714.

Human major histocompatibility complex class II invariant chain is expressed on the cell surface.

Europe PMC ID: 1690714


Add a reference

References: 14 entries

Gregers et al. 2003. Int Immunol. 15(11):1291-9. PMID: 14565927.

MHC class II loading of high or low affinity peptides directed by Ii/peptide fusion constructs: implications for T cell activation.

Europe PMC ID: 14565927

Nordeng et al. 2002. Mol Biol Cell. 13(6):1846-56. PMID: 12058053.

The cytoplasmic tail of invariant chain regulates endosome fusion and morphology.

Europe PMC ID: 12058053

Nordeng et al. 1999. J Biol Chem. 274(30):21139-48. PMID: 10409667.

Overexpression of proteins containing tyrosine- or leucine-based sorting signals affects transferrin receptor trafficking.

Europe PMC ID: 10409667

Moldenhauer et al. 1999. Immunology. 96(3):473-84. PMID: 10233730.

Surface-expressed invariant chain (CD74) is required for internalization of human leucocyte antigen-DR molecules to early endosomal compartments.

Europe PMC ID: 10233730

Rudy et al. 1997. J Immunol. 158(5):2116-25. PMID: 9036956.

The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of B lymphoblastoid cells.

Europe PMC ID: 9036956

Koch et al. 1991. J Immunol. 147(8):2643-51. PMID: 1918985.

Rapid intracellular pathway gives rise to cell surface expression of the MHC class II-associated invariant chain (CD74).

Europe PMC ID: 1918985

Wraight et al. 1990. J Biol Chem. 265(10):5787-92. PMID: 1690714.

Human major histocompatibility complex class II invariant chain is expressed on the cell surface.

Europe PMC ID: 1690714


Add a reference

References: 14 entries

Gregers et al. 2003. Int Immunol. 15(11):1291-9. PMID: 14565927.

MHC class II loading of high or low affinity peptides directed by Ii/peptide fusion constructs: implications for T cell activation.

Nordeng et al. 2002. Mol Biol Cell. 13(6):1846-56. PMID: 12058053.

The cytoplasmic tail of invariant chain regulates endosome fusion and morphology.

Nordeng et al. 1999. J Biol Chem. 274(30):21139-48. PMID: 10409667.

Overexpression of proteins containing tyrosine- or leucine-based sorting signals affects transferrin receptor trafficking.

Moldenhauer et al. 1999. Immunology. 96(3):473-84. PMID: 10233730.

Surface-expressed invariant chain (CD74) is required for internalization of human leucocyte antigen-DR molecules to early endosomal compartments.

Rudy et al. 1997. J Immunol. 158(5):2116-25. PMID: 9036956.

The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of B lymphoblastoid cells.

Koch et al. 1991. J Immunol. 147(8):2643-51. PMID: 1918985.

Rapid intracellular pathway gives rise to cell surface expression of the MHC class II-associated invariant chain (CD74).

Wraight et al. 1990. J Biol Chem. 265(10):5787-92. PMID: 1690714.

Human major histocompatibility complex class II invariant chain is expressed on the cell surface.


Add a reference


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