Anti-Cereblon [3B12F7] monoclonal antibody
Invented at Ohio State University
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Info
| Catalogue Number | 157947 |
| Applications | IHC WB |
| Antigen/Gene or Protein Targets | Cereblon |
| Relevance | Cereblon (CRBN) is a 51 kDa protein encoded by the gene CRBN. This protein is a target of the immunomodulatory drugs thalidomide, lenalidomide, and pomalidomide that show substantial activity in several hematologic cancers, including multiple myeloma, acute myeloid leukemia, and chronic lymphocytic leukemia. Cereblon protein is known to bind calcium-activated potassium channels (KCNMA1 subtype) and mutations in the CRBN gene are linked to cognitive defects, including intellectual disability. Cereblon also interacts with E3 ubiquitin ligase and may play a key role in limb outgrowth in embryos. |
| Host | Mouse |
| Immunogen | Peptide corresponding to sequence near the N-terminus of human cereblon |
| Immunogen UniProt ID | CRBN_HUMAN |
| Molecular Weight (kDa) | 51 |
| Research Area | Cancer, Neurobiology |
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