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Anti-SIGLEC1 [HSn 7D2]


Catalogue Number 151199
Antigen/Gene or Protein Targets Sialoadhesin domains 1-4 (SIGLEC1)
Synonyms CD169, Sialoadhesin 1
Reactivity Human
Relevance The siglecs are a family of membrane bound lectins (of the immunoglobulin superfamily) that bind sialic acid and mediate cell-cell interactions. Family members include sialoadhesin, CD22 and CD33. Sialoadhesin is a macrophage-specific cell adhesion molecule that is expressed on activated macrophages in chronic inflammation and in tumours.
Host Mouse
Immunogen Fc fusion protein containing N-terminal 4 domains of human sialoadhesin.
Subclass IgG1
Positive Control Human spleen (IHC), human peripheral blood monocytes (FACS) or MCF7 cells (IF)
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Notes HSn 7D2 is recommended for cryostat sections and will stain paraffin sections after protease treatment. Detailed procedures for de-paraffinisation are contained in the Steiniger paper.
Research Area Adhesion, Cancer, Immunology

References: 5 entries

Puryear et al. 2013. PLoS Pathog. 9(4):e1003291. PMID: 23593001.

Rempel et al. 2008. PLoS One. 3(4):e1967. PMID: 18414664.

Pack et al. 2008. Immunology. 123(3):438-46. PMID: 17944899.

Hartnell et al. 2001. Blood. 97(1):288-96. PMID: 11133773.

Steiniger et al. 1997. Immunology. 92(2):307-16. PMID: 9415041.

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