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Anti-Keratin18 [LC18N]


Catalogue Number 151202
Applications IHC IF WB
Antigen/Gene or Protein Targets Keratin 18
Reactivity Human
Relevance Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 8 and 18 are two of the first keratins expressed in the embryo, and persist into adult tissues as the keratin pair representing minimal epithelial keratin expression. Keratins 8 and 18 are major components of all simple epithelia (but not of stratified squamous epithelia) and adenocarcinomas.
Host Mouse
Immunogen Synthetic pepide of N terminus of human keratin 18 (NH2- SFTTRSTFSC)
Subclass IgG1
Positive Control HT29 cell line, skin, breast or lung carcinoma
Recommended Growing Conditions DMEM + 5% FCS
Notes Does not cross react with mouse. Cross reacts with keratin 15
Research Area Cell Signaling & Signal Transduction

References: 1 entry

Porter et al. 2000. Lab Invest. 80(11):1701-10. PMID: 11092530.

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