Cancer Research Technology
Log in Register
Menu

HCT116 CDK2-/- p53-/- cell line

Info

Catalogue Number 156402
Antigen/Gene or Protein Targets Cyclin Dependant Kinase 2 (CDK2)
Parental Line HCT 116
Disease Keywords Cancer
Model Knock-Out
Relevance Cyclin Dependant Kinase 2 (CDK2) is a member of a large family of protein kinases that initiates the principal transitions of the eukaryotic cell cycle. Mutations in the CDKs and/or their inhibitors are associated with several forms of cancer, making cyclin-dependent kinases important drug targets for cancer therapy. Tumor protein 53 (p53), is a transcription factor that regulates the cell cycle and thus functions as a tumor suppressor that is involved in preventing cancer. This CDK2 based knockout, HCT116 CDK2-/- p53-/-, is a cell line with both CDK2 and p53 knocked out.
Research Area Cancer, Drug Discovery & Development

References

There are 1 reference entries for this reagent.

View All References

References: 1 entry

Chung et al. 2010. PLoS Genet. 6(2):e1000863. PMID: 20195506.


Add a reference

References: 1 entry

Chung et al. 2010. PLoS Genet. 6(2):e1000863. PMID: 20195506.


Add a reference

Inventor Information

No inventors are currently linked to this reagent.

Add an inventor