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Catalogue Number 151241
Applications FACS IHC IP WB
Antigen/Gene or Protein Targets Proteasome complex; subunit 5a (PSMA5)
Reactivity Human and Xenopus laevis
Relevance The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMA5 is a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene.
Host Mouse
Immunogen Sub-unit 5a
Subclass IgG1
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Notes Recommended Concentration: 2.5µg/ml.
Research Area Cell Cycle

References

There are 8 reference entries for this reagent.

View All References

References: 8 entries

Liu et al. 2014. J Clin Invest. 124(5):2059-70. PMID: 24691443.

WB

Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators.

Europe PMC ID: 24691443

Kley et al. 2012. Brain. 135(Pt 9):2642-60. PMID: 22961544.

Pathophysiology of protein aggregation and extended phenotyping in filaminopathy.

Europe PMC ID: 22961544

Yi et al. 2010. Cell Tissue Res. 341(2):325-40. PMID: 20526895.

WB

Interference with the 19S proteasomal regulatory complex subunit PSMD4 on the sperm surface inhibits sperm-zona pellucida penetration during porcine fertilization.

Europe PMC ID: 20526895

Arlt et al. 2009. Oncogene. 28(45):3983-96. PMID: 19734940.

IHC

Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2).

Europe PMC ID: 19734940


Add a reference

References: 8 entries

Liu et al. 2014. J Clin Invest. 124(5):2059-70. PMID: 24691443.

WB

Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators.

Kley et al. 2012. Brain. 135(Pt 9):2642-60. PMID: 22961544.

Pathophysiology of protein aggregation and extended phenotyping in filaminopathy.

Yi et al. 2010. Cell Tissue Res. 341(2):325-40. PMID: 20526895.

WB

Interference with the 19S proteasomal regulatory complex subunit PSMD4 on the sperm surface inhibits sperm-zona pellucida penetration during porcine fertilization.

Arlt et al. 2009. Oncogene. 28(45):3983-96. PMID: 19734940.

IHC

Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2).


Add a reference