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Anti-PSMA5 [AH1.1]

Info

Catalogue Number 151241
Applications FACS IHC IP WB
Antigen/Gene or Protein Targets Proteasome complex; subunit 5a (PSMA5)
Reactivity Human and Xenopus laevis
Relevance The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMA5 is a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene.
Host Mouse
Immunogen Sub-unit 5a
Subclass IgG1
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Notes Recommended Concentration: 2.5µg/ml.
Research Area Cell Cycle

References: 4 entries

Liu et al. 2014. J Clin Invest. 124(5):2059-70. PMID: 24691443.

WB

Kley et al. 2012. Brain. 135(Pt 9):2642-60. PMID: 22961544.

Yi et al. 2010. Cell Tissue Res. 341(2):325-40. PMID: 20526895.

WB

Arlt et al. 2009. Oncogene. 28(45):3983-96. PMID: 19734940.

IHC


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