Anti-PSMA5 [AH1.1]
Invented by Julian Gannon from The Francis Crick Institute
Invented at Cancer Research UK London Research Institute: Clare Hall Laboratories
- Datasheet
- References (8)
- Inventor Info
Info
| Catalogue Number | 151241 |
| Applications | FACS IHC IP WB |
| Antigen/Gene or Protein Targets | Proteasome complex; subunit 5a (PSMA5) |
| Reactivity | Human and Xenopus laevis |
| Relevance | The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMA5 is a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. |
| Host | Mouse |
| Immunogen | Sub-unit 5a |
| Subclass | IgG1 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Notes | Recommended Concentration: 2.5µg/ml. |
| Research Area | Cell Cycle |
References: 8 entries
Liu et al. 2014. J Clin Invest. 124(5):2059-70. PMID: 24691443.
WB
Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators.
Europe PMC ID: 24691443
Kley et al. 2012. Brain. 135(Pt 9):2642-60. PMID: 22961544.
Pathophysiology of protein aggregation and extended phenotyping in filaminopathy.
Europe PMC ID: 22961544
Yi et al. 2010. Cell Tissue Res. 341(2):325-40. PMID: 20526895.
WB
Interference with the 19S proteasomal regulatory complex subunit PSMD4 on the sperm surface inhibits sperm-zona pellucida penetration during porcine fertilization.
Europe PMC ID: 20526895
Arlt et al. 2009. Oncogene. 28(45):3983-96. PMID: 19734940.
IHC
Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2).
Europe PMC ID: 19734940
Add a reference
References: 8 entries
Liu et al. 2014. J Clin Invest. 124(5):2059-70. PMID: 24691443.
WB
Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators.
Kley et al. 2012. Brain. 135(Pt 9):2642-60. PMID: 22961544.
Pathophysiology of protein aggregation and extended phenotyping in filaminopathy.
Yi et al. 2010. Cell Tissue Res. 341(2):325-40. PMID: 20526895.
WB
Interference with the 19S proteasomal regulatory complex subunit PSMD4 on the sperm surface inhibits sperm-zona pellucida penetration during porcine fertilization.
Arlt et al. 2009. Oncogene. 28(45):3983-96. PMID: 19734940.
IHC
Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2).
Add a reference
