HtrA3 Monoclonal Antibody (Clone 10H10)

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Inventor Info

Info

Catalogue Number	154231
Applications	ELISA IHC
Antigen/Gene or Protein Targets	Human HtrA3 (high temperature requirement factor A)
Synonyms	HtrA3
Reactivity	Human
Relevance	Potential marker for pe-eclampsia. Detection of endogenous HtrA3 proteins in human serum HtrA3 are oligomeric serine proteases involved in protein quality control , regulate signal transduction in cell growth, apoptosis, inflammation in cancer, arthritis, neurodegenerative and neuromuscuclar disorders, age-related macular degeneration, pregnancy-specific disease preecampsia.
Host	Mouse
Immunogen	HtrA3-L-S305A protein
Immunogen UniProt ID	P83110, HTRA3_HUMAN
Molecular Weight (kDa)	48 kDa (46.9 kDa plus 1 kDa for the His tag)
Myeloma Used	Sp2/0-Ag14
Recommended Growing Conditions	Sp2/0 myeloma cells in the presence of 50% (w/v) polyethylene glycol 1500. Cells resuspendedin Hybridoma Serum Free Medium (Invitrogen), supplemented with 10% (w/v) FCS, HAT medium (Invitrogen) and IL-6 (1:1000 dilution).
Strain	Balb/c
Notes	Can be used in combination with Clone 9C9 to detect all human isoforms of HtrA3 by ELISA; very specific neautralising antibody in human studies
Research Area	Gynaecaology, Reproductive Biology

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23049902

25248123

27932697

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23049902

25248123

27932697

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	Hudson Institute Of Medical Research
	16 reagents listed on Ximbio

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