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Anti-TTP, Polyclonal

Invented by Prof Pavel Kovarik

Info

Catalogue Number 153989
Applications IP WB
Antigen/Gene or Protein Targets Tristetraprolin
Synonyms TTP, ZFP36 Ring Finger Protein, Growth Factor-Inducible Nuclear Protein NUP475 G0/G1 Switch Regulatory Protein 24, RNF162A, Zfp-36, NUP475, G0S24, TIS11
Reactivity Human and Mouse
Relevance Members of the tristetraprolin (TTP) family of RNA binding proteins can bind to adenine/uridine-rich elements (AREs) in the 3’-untranslated regions (3’UTRs) of specific mRNAs, and then promote their turnover. For example, TTP is a component of a negative feedback loop that interferes with TNF-alpha production by destabilizing its mRNA. TTP has been shown to interact with 14-3-3 protein family members, such as YWHAH, and with NUP214, a member of the nuclear pore complex. Mice deficient in TTP develop a complex syndrome of inflammatory diseases.
Host Rabbit
Immunogen 34 C-terminal amino acids of TTP fused to GST
Molecular Weight (kDa) 36 kDa
Research Area Cell Signaling & Signal Transduction, Gene Expression, Immunology

References

There are 6 reference entries for this reagent.

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References: 6 entries

Sedlyarov et al. 2016. Mol Syst Biol. 12(5):868. PMID: 27178967.

Tristetraprolin binding site atlas in the macrophage transcriptome reveals a switch for inflammation resolution.

Europe PMC ID: 27178967

Kratochvill et al. 2011. Mol Syst Biol. 7:560. PMID: 22186734.

Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in inflammation.

Europe PMC ID: 22186734

Schaljo et al. 2009. J Immunol. 183(2):1197-206. PMID: 19542371.

Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10.

Europe PMC ID: 19542371


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References: 6 entries

Sedlyarov et al. 2016. Mol Syst Biol. 12(5):868. PMID: 27178967.

Tristetraprolin binding site atlas in the macrophage transcriptome reveals a switch for inflammation resolution.

Kratochvill et al. 2011. Mol Syst Biol. 7:560. PMID: 22186734.

Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in inflammation.

Schaljo et al. 2009. J Immunol. 183(2):1197-206. PMID: 19542371.

Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10.


Add a reference

Inventor Information