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Catalogue Number 153788
Backbone Size (bp) 3461
Bacterial Resistance Ampicillin
Vector Type pQE30
Synonyms TARDBP, TAR DNA Binding Protein, TDP-43, TAR DNA-Binding Protein 43, ALS10
Antigen/Gene or Protein Targets Mutant TDP-43 N-terminal domain 1-102
Relevance The TAR DNA-binding protein (TDP-43) is a highly conserved heterogeneous nuclear ribonucleoprotein (hnRNP) that controls the transcription, splicing and RNA stability of specific genes. The protein associates with single-stranded RNA and DNA sequences, and exhibits remarkable specificity for UG/TG dinucleotide repeats. Regulation of the human low-molecular-weight neurofilament (hNFL) by TDP-43 has also been reported to occur through 3′ UTR recruitment. TDP-43 is the major protein in inclusions from patients suffering from frontotemporal lobar degeneration (FTLD) with ubiquitin-positive inclusions and amyotrophic lateral sclerosis (ALS). This is a mutant N-terminal domain of TDP-43 that cannot fold properly
Research Area Gene Expression, Neurobiology, Virology
Notes Concentration 0.8mg/ml

References

There are 2 reference entries for this reagent.

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References: 2 entries
RECENTLY UPDATED

Mompeán et al. 2017. J Biol Chem. 292(28):11992-12006. PMID: 28566288.

Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions.

Europe PMC ID: 28566288


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References: 2 entries
RECENTLY UPDATED

Mompeán et al. 2017. J Biol Chem. 292(28):11992-12006. PMID: 28566288.

Point mutations in the N-terminal domain of transactive response DNA-binding protein 43 kDa (TDP-43) compromise its stability, dimerization, and functions.


Add a reference