Anti-SATB1, Polyclonal [SATB1]
- Datasheet
- References (0)
- Inventor Info
Info
| Applications | ELISA IF WB |
| Antigen/Gene or Protein Targets | SATB1 |
| Reactivity | Human and Mouse |
| Relevance | Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma By similarity. Binds to DNA at special ATrich sequences, the consensus SATB1binding sequence (CSBS), at nuclear matrix or scaffoldassociated regions. Thought to recognize the sugarphosphate structure of doublestranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated statusdependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatinloop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHCI locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune Tcell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta and gammaglobin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alulike motifs and SATB1binding sites provide a unique chromatin context which seems preferentially targeted by the HIV1 integration machinery. Moreover, HIV1 Tat may overcome SATB1mediated repression of IL2 and IL2RA (interleukin) in Tcells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly upregulating metastasisassociated genes while downregulating tumorsuppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. |
| Host | Rabbit |
| Immunogen | 3 synthetic peptides (human) conjugated to KLH |
| Formulation | 0.5 X PBS, containing a final concentration of 50% Glycerol, 0.1% BSA and 0.01% Thimerosal. |
| Method of Purification | Immunogen affinity purification |
| Molecular Weight (kDa) | 89.1 & 86 |
| Research Area | Epigenetics & Nuclear Signalling |
References
There are 0 reference entries for this reagent.
References: 0 entry
There is no reference for this reagent yet, feel free to use the button below to suggest one.
Add a reference
References: 0 entry
There is no reference for this reagent yet, feel free to use the button below to suggest one.
Add a reference
