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Anti-SATB1, Polyclonal [SATB1]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets SATB1
Reactivity Human and Mouse
Relevance Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma By similarity. Binds to DNA at special AT­rich sequences, the consensus SATB1­binding sequence (CSBS), at nuclear matrix­ or scaffold­associated regions. Thought to recognize the sugar­phosphate structure of double­stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status­dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin­loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC­I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T­cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta­ and gamma­globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu­like motifs and SATB1­binding sites provide a unique chromatin context which seems preferentially targeted by the HIV­1 integration machinery. Moreover, HIV­1 Tat may overcome SATB1­mediated repression of IL2 and IL2RA (interleukin) in T­cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up­regulating metastasis­associated genes while down­regulating tumor­suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.
Host Rabbit
Immunogen 3 synthetic peptides (human) conjugated to KLH
Formulation 0.5 X PBS, containing a final concentration of 50% Glycerol, 0.1% BSA and 0.01% Thimerosal.
Method of Purification Immunogen affinity purification
Molecular Weight (kDa) 89.1 & 86  
Research Area Epigenetics & Nuclear Signalling

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