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Anti-MEF2A, Polyclonal [MEF2A]

Info

Applications ELISA WB
Antigen/Gene or Protein Targets MEF2A
Reactivity Human and Mouse
Relevance Transcriptional activator which binds specifically to the MEF2 element, 5'­ YTA[AT]4TAR­3', found in numerous muscle­specific genes. Also involved in the activation of numerous growth factor­ and stress­induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle­specific and/or growth factor­related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation
Host Rabbit
Immunogen 3 synthetic peptides (human) conjugated to KLH
Molecular Weight (kDa) 54.811 (Isoform MEF2), 54.442 (Isoform MEFA), 53.596 (Isoform RSRFC4), 53.227 (Isoform RSRFC9) and 53.852 (Isoform 5).
Research Area Cardiovascular, Epigenetics & Nuclear Signalling, Neurobiology

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