Anti-MEF2A, Polyclonal [MEF2A]
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Info
| Applications | ELISA WB |
| Antigen/Gene or Protein Targets | MEF2A |
| Reactivity | Human and Mouse |
| Relevance | Transcriptional activator which binds specifically to the MEF2 element, 5' YTA[AT]4TAR3', found in numerous musclespecific genes. Also involved in the activation of numerous growth factor and stressinduced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in musclespecific and/or growth factorrelated transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation |
| Host | Rabbit |
| Immunogen | 3 synthetic peptides (human) conjugated to KLH |
| Molecular Weight (kDa) | 54.811 (Isoform MEF2), 54.442 (Isoform MEFA), 53.596 (Isoform RSRFC4), 53.227 (Isoform RSRFC9) and 53.852 (Isoform 5). |
| Research Area | Cardiovascular, Epigenetics & Nuclear Signalling, Neurobiology |
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