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Anti-EZH1, Polyclonal [EZH1]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets EZH1
Reactivity Human and Mouse
Relevance Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED­EZH1 complex, which methylates 'Lys­27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono­, di­ and trimethylate 'Lys­27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self­renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH1­containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation
Host Rabbit
Immunogen 3 synthetic peptides (human) conjugated to KLH
Molecular Weight (kDa) 85.2   
Research Area Epigenetics & Nuclear Signalling, Stem Cell Biology

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