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Cell Lines

BICR 22 Cell Line

Invented by Prof Eric Kenneth Parkinson from Queen Mary University of London
Invented at Cancer Research UK Glasgow: The Beatson Institute
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BICR 22 Cell Line. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC)
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Catalogue Number 152844
Host Human
Tissue Tongue
Disease Keywords Tongue squamous carcinoma (lymph node metastasis)
Model Tumour line
Relevance Adherent cell line derived from a lymph node metastasis squamous cell carcinoma of the tongue of a Caucasian male. Keratin and involucrin markers present. Known mutations: p53, p16 and p14ARF. Cells are tumourigenic in athymic mice.
Research Area Apoptosis and Programmed Cell Death, Cancer, Drug Discovery & Development, Epigenetics & Nuclear Signalling
Growth/Phenotype Keywords Adherent
Recommended Growing Conditions DMEM + 2mM Glutamine + 10% Foetal Bovine Serum (FBS) + 0.4 micrograms/ml Hydrocortisone.
Notes Amelogenin: X, X
CSF1PO: 11
D13S317: 11,13
D16S539: 11,12
D5S818: 11,12
D7S820: 11,12
THO1: 6,7
TPOX: 8
vWA: 16,19
Cellosaurus ID CVCL_2310

References

There are 2 reference entries for this reagent.

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References: 2 entries

Edington et al. 1995. Mol Carcinog. 13(4):254-65. PMID: 7646764.

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Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss.

Europe PMC ID: 7646764

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References: 2 entries

Edington et al. 1995. Mol Carcinog. 13(4):254-65. PMID: 7646764.

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Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss.

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Inventor Information