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Anti-EXP1 [5.1]

Info

Applications N/A
Antigen/Gene or Protein Targets EXP-1 (allele specific)
Reactivity Plasmodium
Relevance In considering methods for immunological control of Plasmodium falciparum malaria it is essential to know more about antigenic diversity within and between natural populations of the parasite from major endemic areas. A successful malaria vaccine would stimulate an individual's immune system to respond to the malaria parasite and prevent serious clinical disease. Many different groups are currently developing potential vaccines. To survive within its host erythrocyte, Plasmodium falciparum must export hundreds of proteins across both its parasite plasma membrane and surrounding parasitophorous vacuole membrane, most of which are likely to use a protein complex known as PTEX (Plasmodium translocon of exported proteins). he membrane component EXP1 oligomerizes and potentially forms the putative membrane spanning pore to which the remainder of the PTEX complex is attached, and is therefore a good target.
Host Mouse
Immunogen Schizont extracts (K1 isolate)
Subclass IgG1
Notes Recognises blood stage antigen EXP-1. Will only recognise parasites with an aspartic acid (D) residue at position 136 (e.g. K1 isolate). Does not recognise parasites with Glycine at the same position (Palo Alto, HB3, 3D7)
UK Biosafety level: 1
Research Area Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Parasitology

References: 1 entry

Hall et al. 1983. Mol Biochem Parasitol. 7(3):247-65. PMID: 6350871.


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References: 1 entry

Hall et al. 1983. Mol Biochem Parasitol. 7(3):247-65. PMID: 6350871.


Add a reference

References: 1 entry

Hall et al. 1983. Mol Biochem Parasitol. 7(3):247-65. PMID: 6350871.


Add a reference


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