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Anti-p21 [SXM30]

Info

Applications IHC IF IP WB
Antigen/Gene or Protein Targets p21
Synonyms Cyclin-Dependent Kinase Inhibitor 1A; CDK-Interacting Protein 1; CDKN1; CAP20; MDA-6; CIP1; SDI1; WAF1; P21; Melanoma Differentiation Associated Protein 6; Wild-Type P53-Activated Fragment 1; CDK-Interaction Protein 1; DNA Synthesis Inhibitor; P21CIP1; MDA6; PIC1
Reactivity Human, Mouse and Rat
Relevance p21 (Cyclin-Dependent Kinase Inhibitor 1A, CIP1) regulates cell cycle progression, terminal differentiation, and apoptosis. p21 was shown to be induced by p53 and to be a potent inhibitor of cyclin-dependent kinase (CDK) activity. DNA damage leads to increased expression of p21 in cyclin E-containing complexes and to an associated decrease in cyclin-dependent kinase activity. p21 is a critical downstream effector in the p53-specific pathway of growth control in mammalian cells.
Host Mouse
Subclass IgG1
Research Area Cancer, Cell Cycle, DNA Damage and Repair, Epigenetics & Nuclear Signalling

References

There are 1 reference entries for this reagent.

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References: 1 entry

Fredersdorf et al. 1996. Am J Pathol. 148(3):825-35. PMID: 8774137.


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References: 1 entry

Fredersdorf et al. 1996. Am J Pathol. 148(3):825-35. PMID: 8774137.


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