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Anti-CyclinD1 [LX014]

Info

Applications WB
Antigen/Gene or Protein Targets CD1
Synonyms CCND1; B-Cell Lymphoma 1 Protein; B-Cell CLL/Lymphoma; BCL-1 Oncogene; PRAD1; G1/S-Specific Cyclin D1; D11S287E; U21B31
Reactivity Human
Relevance The family of D-type cyclins (D1, D2, and D3) regulates the G1/S-phase transition. D cyclins bind and activate cyclin-dependent kinases (Cdk4 and Cdk6) to phosphorylate the retinoblastoma (pRb) protein, and through titration of the Cdk inhibitors p21Cip1 and p27Kip1, the cyclin D–Cdk4/6 complexes activate cyclin E/Cdk2. Genetic analysis studies in mice have demonstrated an essential role for cyclin D1 in normal development of the retina, components of the nervous system, and terminal alveolar breast bud development.
Host Mouse
Research Area Cancer, Cell Cycle, Epigenetics & Nuclear Signalling, Neurobiology

References: 1 entry

Zhang et al. 2005. Blood. 105(9):3691-8. PMID: 15665120.


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References: 1 entry

Zhang et al. 2005. Blood. 105(9):3691-8. PMID: 15665120.


Add a reference

References: 1 entry

Zhang et al. 2005. Blood. 105(9):3691-8. PMID: 15665120.


Add a reference


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