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Applications
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WB
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Antigen/Gene or Protein Targets
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CD1
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Synonyms
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CCND1; B-Cell Lymphoma 1 Protein; B-Cell CLL/Lymphoma; BCL-1 Oncogene; PRAD1; G1/S-Specific Cyclin D1; D11S287E; U21B31
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Reactivity
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Human
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Relevance
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The family of D-type cyclins (D1, D2, and D3) regulates the G1/S-phase transition. D cyclins bind and activate cyclin-dependent kinases (Cdk4 and Cdk6) to phosphorylate the retinoblastoma (pRb) protein, and through titration of the Cdk inhibitors p21Cip1 and p27Kip1, the cyclin D–Cdk4/6 complexes activate cyclin E/Cdk2. Genetic analysis studies in mice have demonstrated an essential role for cyclin D1 in normal development of the retina, components of the nervous system, and terminal alveolar breast bud development.
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Host
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Mouse
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Research Area
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Cancer, Cell Cycle, Epigenetics & Nuclear Signalling, Neurobiology
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