Anti-NCOA2 [3Ti-3F1]
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Info
| Applications | ELISA IF WB |
| Antigen/Gene or Protein Targets | NCOA2 |
| Reactivity | N/A |
| Relevance | Nuclear receptor coactivator 2 (NCOA2) functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. It acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. NCOA2, together with NCOA1 is required to control energy balance between white and brown adipose. This gene has been found to be involved in translocations resulting in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. |
| Host | Mouse |
| Immunogen | Recomb prot |
| Subclass | IgG1 kappa |
| Notes | Available in 100ul unit |
| Research Area | Epigenetics & Nuclear Signalling |
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