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Anti-Trim33 [5Tg-3E9]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets  TIF1 Gamma 
Synonyms TRIM33
Reactivity N/A
Relevance Tripartite motif-containing 33 (TRIM33) also known as transcriptional intermediary factor 1 gamma (TIF1-γ) acts as an E3 ubiquitin-protein ligase and promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. TRIM33 may act as a transcriptional repressor to inhibit the transcriptional response to TGF-beta/BMP signaling cascade. TRIM33 plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. It monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade. TRIM33 has been shown to interact with TRIM24. Defects in TRIM33 are a cause of thyroid papillary carcinoma (TPC), a common tumor of the thyroid.
Host Mouse
Immunogen AENKGGGEAESGGGGSG
Subclass IgG1 kappa
Notes Available in 100ul unit
Research Area Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Protein Degradation, Stem Cell Biology

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