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Anti-GTF2H2 [13TF2-1H5]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets  TFIIHp44 
Reactivity N/A
Relevance General transcription factor IIH subunit 2 (T-BTF2P44, GTF2H2) is a component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter. Deletion of GTF2H2 sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype.
Host Mouse
Immunogen MDEEPERTKRWEGGYE
Subclass IgG1 kappa
Notes Available in 100ul unit
Research Area Epigenetics & Nuclear Signalling

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