Anti-TBP [3TF1-3G3]
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Info
| Applications | ELISA IF WB |
| Antigen/Gene or Protein Targets | TBP |
| Reactivity | N/A |
| Relevance | TATA-binding protein (TBP) is a general transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Defects in TBP are the cause of spinocerebellar ataxia type 17 (SCA17). The molecular defect in SCA17 is the expansion of a CAG repeat in the coding region of TBP. Longer expansions result in earlier onset and more severe clinical manifestations of the disease. |
| Host | Mouse |
| Immunogen | Recomb prot |
| Subclass | IgG1 kappa |
| Notes | Available in 100ul unit |
| Research Area | Epigenetics & Nuclear Signalling, Gene Expression |
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