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Anti-TBP [3TF1-3G3]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets  TBP 
Reactivity N/A
Relevance TATA-binding protein (TBP) is a general transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Defects in TBP are the cause of spinocerebellar ataxia type 17 (SCA17). The molecular defect in SCA17 is the expansion of a CAG repeat in the coding region of TBP. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.
Host Mouse
Immunogen Recomb prot
Subclass IgG1 kappa
Notes Available in 100ul unit
Research Area Epigenetics & Nuclear Signalling, Gene Expression

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