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Anti-PGR [PR-6A]

Info

Applications ELISA IHC IF WB
Antigen/Gene or Protein Targets  Progesterone receptor 
Reactivity Chicken and Human
Relevance The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation. Isoform A: inactive in stimulating c-Src/MAPK signaling on hormone stimulation. Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
Host Mouse
Immunogen AGMVKPLLFHKK
Subclass IgG2a kappa
Notes Available in 100ul unit

The peptide used as immunogen for this product corresponds to the C terminal sequence of the human PR (end of E region – Hormone binding domain) : 922 AGMVKPLLFHKK 933.

This antibody cross reacts with chicken PR and should also work on rabbit PR since the sequence is 100 % conserved between human, chicken and rabbit.
Research Area Epigenetics & Nuclear Signalling

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