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Anti-HTT [4HU-2C1]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets  Huntingtin 
Reactivity Human
Relevance Defects in HTT are the cause of Huntington disease (HD) [MIM:143100]. HD is an autosomal dominant neurodegenerative disorder characterized by involuntary movements (chorea), general motor impairment, psychiatric disorders and dementia. Onset of the disease occurs usually in the third or fourth decade of life and symptoms progressively worsen leading to death in 10 to 20 years. Onset and clinical course depend on the degree of poly-Gln repeat expansion, longer expansions resulting in earlier onset and more severe clinical manifestations. HD affects 1 in 10,000 individuals of European origin. Neuropathology of Huntington disease displays a distinctive pattern with loss of neurons, especially in the caudate and putamen (striatum).
Host Mouse
Immunogen Recomb prot (2683-2979)
Subclass IgG1 kappa
Notes Available in 100ul unit
Research Area Neurobiology

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