Log in Register
Menu

Anti-FMRP [1C3-1a]

Info

Applications ELISA IHC IF WB
Antigen/Gene or Protein Targets  FMRP (Fragile X retardation protein)
Reactivity Human and Mouse
Relevance The monoclonal anti‐FMRP (Fragile X Mental Retardation Protein), clone 1C3‐1a recognises human and mouse FMRP. The epitope is localised in the N‐terminal half of FMRP. Cross‐reaction with FXR proteins may be detected in case of high expression of these
proteins. FMRP, most commonly found in the brain, is essential for normal cognitive development and female reproductive function. Mutations of this gene can lead to fragile X syndrome, mental retardation, premature ovarian failure, autism, Parkinson's disease, developmental delays and other cognitive deficits. The FMR1 gene is located on the X chromosome and contains a DNA segment called CGG trinucleotide. In most people, the CGG segment is repeated in the gene approximately 5-44 times. Increased expression of the CGG segment on the FMR1 gene is associated with impaired cognitive and reproductive function.
Host Mouse
Immunogen Fusion protein with full length FMRP (human).
Subclass IgG1 kappa
Notes Available in 100ul unit as ascites.

Applications :
- ELISA
- Western Blot (natural and recombinant proteins)
- Immunohistochemistry (frozen and paraffin sections)
- Immunocytochemistry (on transfected cells or not)
- Detection of FMRP on blood smears
- Immunoprecipitation : weak

Recommended dilutions : 1/500 ‐ 1/5000
Research Area Cell Cycle, Epigenetics & Nuclear Signalling, Neurobiology

References: 4 entries

Lugenbeel et al. 1995. Nat Genet. 10(4):483-5. PMID: 7670500.

Khandjian et al. 1995. Hum Mol Genet. 4(5):783-9. PMID: 7633436.

Willemsen et al. 1995. Lancet. 345(8958):1147-8. PMID: 7723547.

Devys et al. 1993. Nat Genet. 4(4):335-40. PMID: 8401578.


Add a reference

References: 4 entries

Lugenbeel et al. 1995. Nat Genet. 10(4):483-5. PMID: 7670500.

Khandjian et al. 1995. Hum Mol Genet. 4(5):783-9. PMID: 7633436.

Willemsen et al. 1995. Lancet. 345(8958):1147-8. PMID: 7723547.

Devys et al. 1993. Nat Genet. 4(4):335-40. PMID: 8401578.


Add a reference

References: 4 entries

Lugenbeel et al. 1995. Nat Genet. 10(4):483-5. PMID: 7670500.

Khandjian et al. 1995. Hum Mol Genet. 4(5):783-9. PMID: 7633436.

Willemsen et al. 1995. Lancet. 345(8958):1147-8. PMID: 7723547.

Devys et al. 1993. Nat Genet. 4(4):335-40. PMID: 8401578.


Add a reference


This reagent does not have any reviews at the moment.