Anti-FMRP [1C3-1a]
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| Applications | ELISA IHC IF WB |
| Antigen/Gene or Protein Targets | FMRP (Fragile X retardation protein) |
| Reactivity | Human and Mouse |
| Relevance |
The monoclonal anti‐FMRP (Fragile X Mental Retardation Protein), clone 1C3‐1a recognises human and mouse FMRP. The epitope is localised in the N‐terminal half of FMRP. Cross‐reaction with FXR proteins may be detected in case of high expression of these proteins. FMRP, most commonly found in the brain, is essential for normal cognitive development and female reproductive function. Mutations of this gene can lead to fragile X syndrome, mental retardation, premature ovarian failure, autism, Parkinson's disease, developmental delays and other cognitive deficits. The FMR1 gene is located on the X chromosome and contains a DNA segment called CGG trinucleotide. In most people, the CGG segment is repeated in the gene approximately 5-44 times. Increased expression of the CGG segment on the FMR1 gene is associated with impaired cognitive and reproductive function. |
| Host | Mouse |
| Immunogen | Fusion protein with full length FMRP (human). |
| Subclass | IgG1 kappa |
| Notes |
Available in 100ul unit as ascites. Applications : - ELISA - Western Blot (natural and recombinant proteins) - Immunohistochemistry (frozen and paraffin sections) - Immunocytochemistry (on transfected cells or not) - Detection of FMRP on blood smears - Immunoprecipitation : weak Recommended dilutions : 1/500 ‐ 1/5000 |
| Research Area | Cell Cycle, Epigenetics & Nuclear Signalling, Neurobiology |
References: 8 entries
Lugenbeel et al. 1995. Nat Genet. 10(4):483-5. PMID: 7670500.
Intragenic loss of function mutations demonstrate the primary role of FMR1 in fragile X syndrome.
Europe PMC ID: 7670500
Khandjian et al. 1995. Hum Mol Genet. 4(5):783-9. PMID: 7633436.
Willemsen et al. 1995. Lancet. 345(8958):1147-8. PMID: 7723547.
A heterogeneous set of FMR1 proteins is widely distributed in mouse tissues and is modulated in cell culture.
Europe PMC ID: 7633436
Rapid antibody test for fragile X syndrome.
Europe PMC ID: 7723547
Devys et al. 1993. Nat Genet. 4(4):335-40. PMID: 8401578.
The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation.
Europe PMC ID: 8401578
Add a reference
References: 8 entries
Lugenbeel et al. 1995. Nat Genet. 10(4):483-5. PMID: 7670500.
Intragenic loss of function mutations demonstrate the primary role of FMR1 in fragile X syndrome.
Europe PMC ID: 7670500
Khandjian et al. 1995. Hum Mol Genet. 4(5):783-9. PMID: 7633436.
Willemsen et al. 1995. Lancet. 345(8958):1147-8. PMID: 7723547.
A heterogeneous set of FMR1 proteins is widely distributed in mouse tissues and is modulated in cell culture.
Europe PMC ID: 7633436
Rapid antibody test for fragile X syndrome.
Europe PMC ID: 7723547
Devys et al. 1993. Nat Genet. 4(4):335-40. PMID: 8401578.
The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation.
Europe PMC ID: 8401578
Add a reference
References: 8 entries
Lugenbeel et al. 1995. Nat Genet. 10(4):483-5. PMID: 7670500.
Intragenic loss of function mutations demonstrate the primary role of FMR1 in fragile X syndrome.
Khandjian et al. 1995. Hum Mol Genet. 4(5):783-9. PMID: 7633436.
Willemsen et al. 1995. Lancet. 345(8958):1147-8. PMID: 7723547.
A heterogeneous set of FMR1 proteins is widely distributed in mouse tissues and is modulated in cell culture.
Rapid antibody test for fragile X syndrome.
Devys et al. 1993. Nat Genet. 4(4):335-40. PMID: 8401578.
The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation.
Add a reference
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