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Anti-Esr2 [4ERß-2D7]

Info

Applications ELISA IHC IF WB
Antigen/Gene or Protein Targets  Estrogen receptor b (F region) 
Reactivity Human and Mouse
Relevance The Monoclonal anti‐ERß (F‐region) Clone 4ERß‐2D7 reacts on ERß from mouse and human origin. No cross‐reactivity has been observed on ER alpha. It has been validated for ELISA, Western Blot (natural and recombinant proteines), Immunofluorescence and Immunohistochemistry. Estrogen receptors are activated by the hormone estrogen (17β-estradiol). Once activated by estrogen, the ER is able to translocate into the nucleus and acts as a a DNA-binding transcription factor. ERa and ERb regulate gene transcription by direct binding to estrogen-regulated elements (ERE) or indirectly by protein-protein interaction with transcription factor activator protein-1 (AP-1) and Sp1. Estrogens are important for mammary gland morphogenesis and differentiation.
Host Mouse
Immunogen CCSTEDSKSKEGSQNLQSQ (synthetic peptide derived from the Fregion of mouse ERß)
Subclass IgG1 kappa
Notes Available in 100ul unit as ascites,
Research Area Cancer, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Neurobiology

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