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Anti-ESR1 [ER-B10]

Info

Applications ELISA IHC IF WB
Antigen/Gene or Protein Targets  Estrogen receptor a (B region) 
Reactivity Human
Relevance The Monoclonal Anti‐Human Estrogen Receptor a (B10) does not react with chicken, and other reactivities have not been tested. Estrogen receptors are activated by the hormone estrogen (17β-estradiol). Once activated by estrogen, the ER is able to translocate into the nucleus and acts as a a DNA-binding transcription factor. ERa and ERb regulate gene transcription by direct binding to estrogen-regulated elements (ERE) or indirectly by protein-protein interaction with transcription factor activator protein-1 (AP-1) and Sp1. Estrogens are important for mammary gland morphogenesis and differentiation.
Host Mouse
Immunogen RPNSDNRRQGGRERL (corresponds to the amino‐acid sequence 151‐ 165 from human ER (B region))
Subclass IgG2a kappa
Notes Available in 100ul unit as ascites.

- Immunohistochemistry : frozen section and microwave oven treated paraffin sections (Suggested dilution 1/1000‐1/2000)
- Immunocytochemistry (Suggested dilution 1/1000‐1/2000)
- Elisa (Suggested dilution 1/1000‐1/2000)
- Western Blot dilution (Suggested dilution 1/1000‐1/2000)
- Immunoprecipitation (Suggested dilution 1/10)
- Gels super shift assay (Suggested dilution 1/10)
- ChIP
Research Area Cancer, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Neurobiology

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