Anti-ESR1 [ER-B10]
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Info
| Applications | ELISA IHC IF WB |
| Antigen/Gene or Protein Targets | Estrogen receptor a (B region) |
| Reactivity | Human |
| Relevance | The Monoclonal Anti‐Human Estrogen Receptor a (B10) does not react with chicken, and other reactivities have not been tested. Estrogen receptors are activated by the hormone estrogen (17β-estradiol). Once activated by estrogen, the ER is able to translocate into the nucleus and acts as a a DNA-binding transcription factor. ERa and ERb regulate gene transcription by direct binding to estrogen-regulated elements (ERE) or indirectly by protein-protein interaction with transcription factor activator protein-1 (AP-1) and Sp1. Estrogens are important for mammary gland morphogenesis and differentiation. |
| Host | Mouse |
| Immunogen | RPNSDNRRQGGRERL (corresponds to the amino‐acid sequence 151‐ 165 from human ER (B region)) |
| Subclass | IgG2a kappa |
| Notes |
Available in 100ul unit as ascites. - Immunohistochemistry : frozen section and microwave oven treated paraffin sections (Suggested dilution 1/1000‐1/2000) - Immunocytochemistry (Suggested dilution 1/1000‐1/2000) - Elisa (Suggested dilution 1/1000‐1/2000) - Western Blot dilution (Suggested dilution 1/1000‐1/2000) - Immunoprecipitation (Suggested dilution 1/10) - Gels super shift assay (Suggested dilution 1/10) - ChIP |
| Research Area | Cancer, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Neurobiology |
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