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Anti-CSA [3CSA-2A7]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets  CSA (Cockayne syndrome A protein) 
Reactivity Human
Relevance Monoclonal anti-CSA, clone 3CSA-2A7, has been validated for ELISA, Western Blot, Immunoprecipitation and Immunocytochemistry. Cockayne syndrome (CS), also called Neill-Dingwall syndrome, is a rare autosomal recessive neurodegenerative disorder characterized by growth failure, impaired development of the nervous system, abnormal sensitivity to sunlight (photosensitivity), eye disorders and premature aging. Mutations in the ERCC8 (also known as CSA) gene or the ERCC6 (also known as CSB) gene are the cause of Cockayne syndrome. Mutations in the ERCC6 gene mutation makes up ~70% of cases. The proteins made by these genes are involved in repairing damaged DNA via the transcription-coupled repair mechanism, particularly the DNA in active genes.
Host Mouse
Immunogen ESTRRVLGLELNKDRDVERIH (Synthetic peptide corresponding to aa 22-42 of human CSA)
Subclass IgG1 kappa
Notes Available in 100ul unit as ascites.

Recommended dilutions: 1/500-1/5000
Research Area DNA Damage and Repair, Epigenetics & Nuclear Signalling, Neurobiology

References: 1 entry

Bradsher et al. 2002. Mol Cell. 10(4):819-29. PMID: 12419226.


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References: 1 entry

Bradsher et al. 2002. Mol Cell. 10(4):819-29. PMID: 12419226.


Add a reference

References: 1 entry

Bradsher et al. 2002. Mol Cell. 10(4):819-29. PMID: 12419226.


Add a reference


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