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Anti-ACTA1 [1ACT-2D7]

Info

Applications IF WB
Antigen/Gene or Protein Targets  Actin 
Reactivity Human, Mouse and Rat
Relevance Clone 1ACT-2D7 recognises human Actin. Actin is a ubiquitous globular protein that is one of the most highly-conserved proteins known. It is found in two intrinsically flexible states; G-actin is the globular monomeric form, whereas F-actin forms helical polymers. Both have a role as a dynamic filament network. Actin has four major functions. Firstly, F-actin polymers form microfilaments - polar intracellular 'tracks' for kinesin motor proteins, allowing the transport of vesicles, organelles and other cargo. Actin is a component of the cytoskeleton and links to alpha-actinin, E-cadherin and beta-catenin at adherens junctions. This gives mechanical support to cells and attaches them to each other and the extracellular matrix. In muscle cells, actin-rich thin filaments associate with myosin-rich thick filaments to form actomyosin myofibrils. Using energy from the hydrolysis of ATP, myofibrils undergo cyclic shortening through actin-myosin head interactions, which represents the mechanics of muscle contraction. Finally, actin has a role in cell motility through polymerization and depolymerization of fibrils.
Host Mouse
Immunogen CYDEAGPSIVHRK
Subclass IgG2a kappa
Notes Available in 100ul unit as ascites.
Research Area Apoptosis and Programmed Cell Death, Cancer, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction

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