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Anti-TCP1 [23c (CTA-123)]


Catalogue Number 151321
Applications IHC IF IP WB
Antigen/Gene or Protein Targets TCP1 (T-complex polypeptide 1)
Reactivity Chicken, Dog, Hamster, Mouse and Rat
Relevance TCP1, (a constituent of chaperone-containing TCP-1, CCT) is a ~60 kDa protein constitutively expressed in almost all eukaryotic cells and upregulated during spermatogenesis. It is found in the cytosol as a subunit of a hetero-oligomeric chaperone that is known to be involved in the folding of actin and tubulin.
Host Rat
Immunogen C-terminal half of the full length murine TCP protein
Subclass IgG2c
Myeloma Used Y3.AG.1.2.3
Recommended Growing Conditions DMEM + 5% FCS
Notes 23C binds protein A and is useful for native precipitation of CCT and golgi coatomer. Does not recognise primate, xenopus or yeast TCP-1.
Research Area Apoptosis and Programmed Cell Death, Cancer, Cell Cycle

References: 4 entries

Lobanova K et al, 2013. PNAS 110(24):9986-91 PMID 23716657

Sternlicht et al. 1993. Proc Natl Acad Sci U S A. 90(20):9422-6. PMID: 8105476.

Harrison-Lavoie et al. 1993. EMBO J. 12(7):2847-53. PMID: 8335000.

Willison et al. 1989. Cell. 57(4):621-32. PMID: 2655925.

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