Anti-TCP1 [23c (CTA-123)]
Invented at The Institute of Cancer Research
- Datasheet
- References (7)
- Inventor Info
Info
| Catalogue Number | 151321 |
| Applications | IHC IF IP WB |
| Antigen/Gene or Protein Targets | TCP1 (T-complex polypeptide 1) |
| Reactivity | Chicken, Dog, Hamster, Mouse and Rat |
| Relevance | TCP1, (a constituent of chaperone-containing TCP-1, CCT) is a ~60 kDa protein constitutively expressed in almost all eukaryotic cells and upregulated during spermatogenesis. It is found in the cytosol as a subunit of a hetero-oligomeric chaperone that is known to be involved in the folding of actin and tubulin. |
| Host | Rat |
| Immunogen | C-terminal half of the full length murine TCP protein |
| Subclass | IgG2c |
| Myeloma Used | Y3.AG.1.2.3 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Notes | 23C binds protein A and is useful for native precipitation of CCT and golgi coatomer. Does not recognise primate, xenopus or yeast TCP-1. |
| Research Area | Apoptosis and Programmed Cell Death, Cancer, Cell Cycle |
References: 7 entries
Lobanova K et al, 2013. PNAS 110(24):9986-91 PMID 23716657
Sternlicht et al. 1993. Proc Natl Acad Sci U S A. 90(20):9422-6. PMID: 8105476.
The t-complex polypeptide 1 complex is a chaperonin for tubulin and actin in vivo.
Europe PMC ID: 8105476
Harrison-Lavoie et al. 1993. EMBO J. 12(7):2847-53. PMID: 8335000.
A 102 kDa subunit of a Golgi-associated particle has homology to beta subunits of trimeric G proteins.
Europe PMC ID: 8335000
Willison et al. 1989. Cell. 57(4):621-32. PMID: 2655925.
The t complex polypeptide 1 (TCP-1) is associated with the cytoplasmic aspect of Golgi membranes.
Europe PMC ID: 2655925
Add a reference
References: 7 entries
Lobanova K et al, 2013. PNAS 110(24):9986-91 PMID 23716657
Sternlicht et al. 1993. Proc Natl Acad Sci U S A. 90(20):9422-6. PMID: 8105476.
The t-complex polypeptide 1 complex is a chaperonin for tubulin and actin in vivo.
Harrison-Lavoie et al. 1993. EMBO J. 12(7):2847-53. PMID: 8335000.
A 102 kDa subunit of a Golgi-associated particle has homology to beta subunits of trimeric G proteins.
Willison et al. 1989. Cell. 57(4):621-32. PMID: 2655925.
The t complex polypeptide 1 (TCP-1) is associated with the cytoplasmic aspect of Golgi membranes.
Add a reference
