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Mouse Models

CLEC2 Floxed KO Mouse

Invented at University Of Birmingham
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Catalogue Number 152150
Antigen/Gene or Protein Targets CLEC2
Disease Keywords Platelet aggregation
Relevance A novel mutant mouse that lacks functional CLEC2 and has been used to investigate the role of CLEC2 in platelet aggregation and thrombus formation. Enables removal of C-type lectin-like receptor type 2 from pertinent cell types when crossed with Cre-recominase expressing mice.
Conditional Yes
Conditional Description Conditional deletion of CLEC2 was achieved by insertion of loxP sites flanking exons 3 and 4 of the Clec1b gene
Mouse Genetic Background/Cross History Mice were bred as heterozygotes on a mixed C57B1/6 x 129Sv background
Zygosity Clec1b -/-
Research Area Genetic Studies Tools, Immunology

References

There are 4 reference entries for this reagent.

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References: 4 entries

Finney et al. 2012. Blood. 119(7):1747-56. PMID: 22186994.

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CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

Europe PMC ID: 22186994

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Hughes et al. 2010. J Thromb Haemost. 8(10):2328-32. PMID: 20695981.

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CLEC-2 is not required for platelet aggregation at arteriolar shear.

Europe PMC ID: 20695981

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References: 4 entries

Finney et al. 2012. Blood. 119(7):1747-56. PMID: 22186994.

View  

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

View  

Hughes et al. 2010. J Thromb Haemost. 8(10):2328-32. PMID: 20695981.

View  

CLEC-2 is not required for platelet aggregation at arteriolar shear.

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Inventor Information

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Invented at

University Of Birmingham
University Of Birmingham

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