Anti-CLEC2 [AYP1]
Invented at University Of Birmingham
Catalogue Number | 152150 |
Antigen/Gene or Protein Targets | CLEC2 |
Disease Keywords | Platelet aggregation |
Relevance | A novel mutant mouse that lacks functional CLEC2 and has been used to investigate the role of CLEC2 in platelet aggregation and thrombus formation. Enables removal of C-type lectin-like receptor type 2 from pertinent cell types when crossed with Cre-recominase expressing mice. |
Conditional | Yes |
Conditional Description | Conditional deletion of CLEC2 was achieved by insertion of loxP sites flanking exons 3 and 4 of the Clec1b gene |
Mouse Genetic Background/Cross History | Mice were bred as heterozygotes on a mixed C57B1/6 x 129Sv background |
Zygosity | Clec1b -/- |
Research Area | Genetic Studies Tools, Immunology |
Finney et al. 2012. Blood. 119(7):1747-56. PMID: 22186994.
CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.
Europe PMC ID: 22186994
Hughes et al. 2010. J Thromb Haemost. 8(10):2328-32. PMID: 20695981.
CLEC-2 is not required for platelet aggregation at arteriolar shear.
Europe PMC ID: 20695981
Finney et al. 2012. Blood. 119(7):1747-56. PMID: 22186994.
CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.
Hughes et al. 2010. J Thromb Haemost. 8(10):2328-32. PMID: 20695981.
CLEC-2 is not required for platelet aggregation at arteriolar shear.