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|Antigen/Gene or Protein Targets||Cytochromes P450 4A1, 2C11. CYP4A1, CYP2C11|
|Relevance||The CYP2 family are part of the microsomal drug metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances. The hepatic CYP4A enzymes are important fatty acid and prostaglandin omega-hydroxylases that are highly inducible by fibric acid hypolipidemic agents and other peroxisome proliferators. In humans, 4A1, 4A2, & 4A3 have been cloned from liver, kidney and testis and have been detected in renal, hepatic & brain microvessels.|
|Immunogen||Rat liver cytochrome P450 2C11 and 4A1|
|Molecular Weight (kDa)||51/51.5|
|Recommended Growing Conditions||DMEM + 5% FCS|
|Research Area||Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism|
References: 3 entries
"Monoclonal Antibodies Diagnostics for Individual Members of the Cytochromes P450IV Gene Family", Abstract 1.36 at the 12th Eur. Work. on Drug Metabolism, Basel, Switzerland, Sept. 16-21, 1990.
"Monoclonal Antibodies Diagnostics for Individual Members of the Cytochromes P450IV Gene Family", Abstract 205 at the VIIIth Inter. Symp. on Microsomes and Drug Oxidations, Stockholm, Sweden, June 25-26, 1990.
Tzeng et al. 2012. Evid Based Complement Alternat Med. 2012:827278. PMID: 22253647.
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