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Anti-PP2R5E-B56 epsilon [5A5-1F3]

Invented by Egon Ogris at Medical University Of Vienna

Info

Applications IHC IP WB
Antigen/Gene or Protein Targets PP2A B56 epsilon
Reactivity Human
Relevance Protein phosphatase 2A (PP2A) is one of the most abundantly expressed serine/threonine protein phosphatases. A large body of evidence suggests that PP2A is a tumor suppressor and plays critical roles in regulating apoptosis. PP2A is a heterotrimeric protein complex. Its substrate specificity, localization, and activity are regulated by regulatory subunits of PP2A. A recent study has demonstrated that single nucleotide polymorphism in B56ε (PPP2R5E), a B56 family regulatory subunit of PP2A, is associated with human soft tissue sarcoma. This raises the possibility that B56ε is involved in tumorigenesis and plays important roles in regulating apoptosis.
Host Mouse
Immunogen Human B56 epsilon residues 2-126
Molecular Weight (kDa) 54.7
Research Area Apoptosis and Programmed Cell Death, Cancer

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