Anti-PP2R5E-B56 epsilon [5A5-1F3]

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Applications	IHC IP WB
Antigen/Gene or Protein Targets	PP2A B56 epsilon
Reactivity	Human
Relevance	Protein phosphatase 2A (PP2A) is one of the most abundantly expressed serine/threonine protein phosphatases. A large body of evidence suggests that PP2A is a tumor suppressor and plays critical roles in regulating apoptosis. PP2A is a heterotrimeric protein complex. Its substrate specificity, localization, and activity are regulated by regulatory subunits of PP2A. A recent study has demonstrated that single nucleotide polymorphism in B56ε (PPP2R5E), a B56 family regulatory subunit of PP2A, is associated with human soft tissue sarcoma. This raises the possibility that B56ε is involved in tumorigenesis and plays important roles in regulating apoptosis.
Host	Mouse
Immunogen	Human B56 epsilon residues 2-126
Molecular Weight (kDa)	54.7
Research Area	Apoptosis and Programmed Cell Death, Cancer

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	Egon Ogris
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	Medical University Of Vienna
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