- Reviews (0)
|Applications||ELISA IHC WB|
|Antigen/Gene or Protein Targets||Hypoxia-inducible factor 2, alpha subunit (HIF2A)|
|Relevance||Induction of the Hif regulated genes, as a consequence of the microenvironment or genetic changes, is known to have an important role in the growth of experimental tumours. HIF2A is predominantly expressed in highly vascularized tissues of adult humans and endothelial cells of the embryonic and adult mouse, whereas HIF1A has been observed in varying subsets of tumour cells from various solid tumours. HIF2A is also a potent activator of the tie2 gene, which is known to be selectively expressed in endothelial cells.|
|Immunogen||GST-human EPAS-1 (HIF2A) amino acids 535-631 fusion protein|
|Recommended Growing Conditions||RPMI + 10% FCS + HAT|
|Research Area||Cancer, Cardiovascular, Epigenetics & Nuclear Signalling, Metabolism|
References: 7 entries
Pacak et al. 2013. J Clin Oncol. 31(13):1690-8. PMID: 23509317.
Neumeister et al. 2012. J Natl Cancer Inst. 104(23):1815-24. PMID: 23090068.
Giatromanolaki et al. 2003. J Pathol. 200(2):222-8. PMID: 12754744.
Hui et al. 2002. Clin Cancer Res. 8(8):2595-604. PMID: 12171890.
Beasley et al. 2002. Cancer Res. 62(9):2493-7. PMID: 11980639.
Talks et al. 2000. Am J Pathol. 157(2):411-21. PMID: 10934146.
Wiesener et al. 1998. Blood. 92(7):2260-8. PMID: 9746763.
Add a reference
Have you used this reagent? Share your experience by submitting a review and help your fellow scientists.Review this reagent