Anti-HIF2A [EP190b]
Invented by Helen Turley from University of Oxford
Invented at University of Oxford
- Datasheet
- References (14)
- Inventor Info
Info
| Catalogue Number | 151263 |
| Applications | ELISA IHC WB |
| Antigen/Gene or Protein Targets | Hypoxia-inducible factor 2, alpha subunit (HIF2A) |
| Reactivity | Human |
| Relevance | Induction of the Hif regulated genes, as a consequence of the microenvironment or genetic changes, is known to have an important role in the growth of experimental tumours. HIF2A is predominantly expressed in highly vascularized tissues of adult humans and endothelial cells of the embryonic and adult mouse, whereas HIF1A has been observed in varying subsets of tumour cells from various solid tumours. HIF2A is also a potent activator of the tie2 gene, which is known to be selectively expressed in endothelial cells. |
| Host | Mouse |
| Immunogen | GST-human EPAS-1 (HIF2A) amino acids 535-631 fusion protein |
| Subclass | IgG1 |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | RPMI + 10% FCS + HAT |
| Strain | Balb/c |
| Research Area | Cancer, Cardiovascular, Epigenetics & Nuclear Signalling, Metabolism |
References: 14 entries
Pacak et al. 2013. J Clin Oncol. 31(13):1690-8. PMID: 23509317.
New syndrome of paraganglioma and somatostatinoma associated with polycythemia.
Europe PMC ID: 23509317
Neumeister et al. 2012. J Natl Cancer Inst. 104(23):1815-24. PMID: 23090068.
Quantitative assessment of effect of preanalytic cold ischemic time on protein expression in breast cancer tissues.
Europe PMC ID: 23090068
Giatromanolaki et al. 2003. J Pathol. 200(2):222-8. PMID: 12754744.
DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer.
Europe PMC ID: 12754744
Hui et al. 2002. Clin Cancer Res. 8(8):2595-604. PMID: 12171890.
Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival.
Europe PMC ID: 12171890
Beasley et al. 2002. Cancer Res. 62(9):2493-7. PMID: 11980639.
Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients.
Europe PMC ID: 11980639
Talks et al. 2000. Am J Pathol. 157(2):411-21. PMID: 10934146.
The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.
Europe PMC ID: 10934146
Wiesener et al. 1998. Blood. 92(7):2260-8. PMID: 9746763.
Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.
Europe PMC ID: 9746763
Add a reference
References: 14 entries
Pacak et al. 2013. J Clin Oncol. 31(13):1690-8. PMID: 23509317.
New syndrome of paraganglioma and somatostatinoma associated with polycythemia.
Neumeister et al. 2012. J Natl Cancer Inst. 104(23):1815-24. PMID: 23090068.
Quantitative assessment of effect of preanalytic cold ischemic time on protein expression in breast cancer tissues.
Giatromanolaki et al. 2003. J Pathol. 200(2):222-8. PMID: 12754744.
DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer.
Hui et al. 2002. Clin Cancer Res. 8(8):2595-604. PMID: 12171890.
Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival.
Beasley et al. 2002. Cancer Res. 62(9):2493-7. PMID: 11980639.
Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients.
Talks et al. 2000. Am J Pathol. 157(2):411-21. PMID: 10934146.
The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.
Wiesener et al. 1998. Blood. 92(7):2260-8. PMID: 9746763.
Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.
Add a reference
