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Anti-HIF2A [EP190b]

Invented by Helen Turley at University of Oxford

Info

Catalogue Number 151263
Applications ELISA IHC WB
Antigen/Gene or Protein Targets Hypoxia-inducible factor 2, alpha subunit (HIF2A)
Reactivity Human
Relevance Induction of the Hif regulated genes, as a consequence of the microenvironment or genetic changes, is known to have an important role in the growth of experimental tumours. HIF2A is predominantly expressed in highly vascularized tissues of adult humans and endothelial cells of the embryonic and adult mouse, whereas HIF1A has been observed in varying subsets of tumour cells from various solid tumours. HIF2A is also a potent activator of the tie2 gene, which is known to be selectively expressed in endothelial cells.
Host Mouse
Immunogen GST-human EPAS-1 (HIF2A) amino acids 535-631 fusion protein
Subclass IgG1
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI + 10% FCS + HAT
Strain Balb/c
Research Area Cancer, Cardiovascular, Epigenetics & Nuclear Signalling, Metabolism

References: 14 entries

Pacak et al. 2013. J Clin Oncol. 31(13):1690-8. PMID: 23509317.

New syndrome of paraganglioma and somatostatinoma associated with polycythemia.

Europe PMC ID: 23509317

Neumeister et al. 2012. J Natl Cancer Inst. 104(23):1815-24. PMID: 23090068.

Quantitative assessment of effect of preanalytic cold ischemic time on protein expression in breast cancer tissues.

Europe PMC ID: 23090068

Giatromanolaki et al. 2003. J Pathol. 200(2):222-8. PMID: 12754744.

DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer.

Europe PMC ID: 12754744

Hui et al. 2002. Clin Cancer Res. 8(8):2595-604. PMID: 12171890.

Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival.

Europe PMC ID: 12171890

Beasley et al. 2002. Cancer Res. 62(9):2493-7. PMID: 11980639.

Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients.

Europe PMC ID: 11980639

Talks et al. 2000. Am J Pathol. 157(2):411-21. PMID: 10934146.

The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.

Europe PMC ID: 10934146

Wiesener et al. 1998. Blood. 92(7):2260-8. PMID: 9746763.

Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.

Europe PMC ID: 9746763


Add a reference

References: 14 entries

Pacak et al. 2013. J Clin Oncol. 31(13):1690-8. PMID: 23509317.

New syndrome of paraganglioma and somatostatinoma associated with polycythemia.

Europe PMC ID: 23509317

Neumeister et al. 2012. J Natl Cancer Inst. 104(23):1815-24. PMID: 23090068.

Quantitative assessment of effect of preanalytic cold ischemic time on protein expression in breast cancer tissues.

Europe PMC ID: 23090068

Giatromanolaki et al. 2003. J Pathol. 200(2):222-8. PMID: 12754744.

DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer.

Europe PMC ID: 12754744

Hui et al. 2002. Clin Cancer Res. 8(8):2595-604. PMID: 12171890.

Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival.

Europe PMC ID: 12171890

Beasley et al. 2002. Cancer Res. 62(9):2493-7. PMID: 11980639.

Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients.

Europe PMC ID: 11980639

Talks et al. 2000. Am J Pathol. 157(2):411-21. PMID: 10934146.

The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.

Europe PMC ID: 10934146

Wiesener et al. 1998. Blood. 92(7):2260-8. PMID: 9746763.

Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.

Europe PMC ID: 9746763


Add a reference

References: 14 entries

Pacak et al. 2013. J Clin Oncol. 31(13):1690-8. PMID: 23509317.

New syndrome of paraganglioma and somatostatinoma associated with polycythemia.

Neumeister et al. 2012. J Natl Cancer Inst. 104(23):1815-24. PMID: 23090068.

Quantitative assessment of effect of preanalytic cold ischemic time on protein expression in breast cancer tissues.

Giatromanolaki et al. 2003. J Pathol. 200(2):222-8. PMID: 12754744.

DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer.

Hui et al. 2002. Clin Cancer Res. 8(8):2595-604. PMID: 12171890.

Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival.

Beasley et al. 2002. Cancer Res. 62(9):2493-7. PMID: 11980639.

Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients.

Talks et al. 2000. Am J Pathol. 157(2):411-21. PMID: 10934146.

The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.

Wiesener et al. 1998. Blood. 92(7):2260-8. PMID: 9746763.

Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.


Add a reference


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