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Anti-HIF2A [EP190b]


Catalogue Number 151263
Applications ELISA IHC WB
Antigen/Gene or Protein Targets Hypoxia-inducible factor 2, alpha subunit (HIF2A)
Reactivity Human
Relevance Induction of the Hif regulated genes, as a consequence of the microenvironment or genetic changes, is known to have an important role in the growth of experimental tumours. HIF2A is predominantly expressed in highly vascularized tissues of adult humans and endothelial cells of the embryonic and adult mouse, whereas HIF1A has been observed in varying subsets of tumour cells from various solid tumours. HIF2A is also a potent activator of the tie2 gene, which is known to be selectively expressed in endothelial cells.
Host Mouse
Immunogen GST-human EPAS-1 (HIF2A) amino acids 535-631 fusion protein
Subclass IgG1
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions RPMI + 10% FCS + HAT
Strain Balb/c
Research Area Cancer, Cardiovascular, Epigenetics & Nuclear Signalling, Metabolism

References: 7 entries

Pacak et al. 2013. J Clin Oncol. 31(13):1690-8. PMID: 23509317.

Neumeister et al. 2012. J Natl Cancer Inst. 104(23):1815-24. PMID: 23090068.

Giatromanolaki et al. 2003. J Pathol. 200(2):222-8. PMID: 12754744.

Hui et al. 2002. Clin Cancer Res. 8(8):2595-604. PMID: 12171890.

Beasley et al. 2002. Cancer Res. 62(9):2493-7. PMID: 11980639.

Talks et al. 2000. Am J Pathol. 157(2):411-21. PMID: 10934146.

Wiesener et al. 1998. Blood. 92(7):2260-8. PMID: 9746763.

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